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  4. Recombinant Rat Amiloride-sensitive sodium channel subunit gamma (Scnn1g), partial

Recombinant Rat Amiloride-sensitive sodium channel subunit gamma (Scnn1g), partial

  • 中文名稱：
    大鼠Scnn1g重組蛋白
  • 貨號：
    CSB-YP020851RA
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    大鼠Scnn1g重組蛋白
  • 貨號：
    CSB-EP020851RA
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    大鼠Scnn1g重組蛋白
  • 貨號：
    CSB-EP020851RA-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    大鼠Scnn1g重組蛋白
  • 貨號：
    CSB-BP020851RA
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    大鼠Scnn1g重組蛋白
  • 貨號：
    CSB-MP020851RA
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Scnn1g
  • Uniprot No.：
  • 別名：
    Scnn1g; Amiloride-sensitive sodium channel subunit gamma; Epithelial Na(+) channel subunit gamma; Gamma-ENaC; Gamma-NaCH; Nonvoltage-gated sodium channel 1 subunit gamma; SCNEG
  • 種屬：
    Rattus norvegicus (Rat)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis, but also in airway surface liquid homeostasis, which is important for proper clearance of mucus. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception.
  • 基因功能參考文獻：
    1. gammaENaC may play an important role in the elevated myogenic response in Posterior Cerebral Arteries. PMID: 28383056
    2. Decreased in plasma aldosterone, Na(+) and ENaC levels in kidneys under testosterone influence indicated that testosterone-induced increased in mean arterial pressure (MAP) were not due to increased plasma aldosterone and ENaC levels in kidneys, and thus the testosterone effect on MAP likely involve other mechanisms. PMID: 28954214
    3. Data suggest that dietary factors can regulate cardiac Scnn1g, Nedd4-2, and Sgk1 activity; here, proanthocyanidin dietary supplement PRO80 blocks aldosterone-dependent up-regulation of Scnn1g, Nedd4-2, and Sgk1 content in cardiac dysfunction. (Scnn1g = epithelial sodium channel 1, gamma subunit; Nedd4-2 = ubiquitin-protein ligase Nedd4-2; Sgk1 = serum-glucocorticoid regulated kinase 1) PMID: 27592201
    4. This study demonstrated that the formation of the heminodal Nav channel cluster adjacent to the presynaptic terminal occurs around hearing onset in the second week of postnatal age. PMID: 27832602
    5. Kidneys respond acutely to hyperkalemic challenges by decreasing the activity of NCC while increasing that of ENaC. PMID: 28356292
    6. This study demonstrated that oestradiol and may augment the expression of ENaC, enhance AFC, attenuate pulmonary oedema by inhibiting 11beta-HSD2 activity, and increase the active glucocorticoid levels. PMID: 26051998
    7. findings provide an allosteric mechanism for ENaC activation regulated by the N termini and sheds light on a potential general mechanism of channel and receptor activation. PMID: 24973914
    8. ENaC and TRPM4 interact in rat posterior cerebral arteries and play important roles in the pressure-induced myogenic response. PMID: 24391909
    9. Modulation of ENaC-mediated Na+ entry in a physiologic context induces parallel changes of Na, K-ATPase activity and expression independently of aldosterone level, confirming the occurrence of intrinsic cross-talk between ENaC and Na,K-ATPase. PMID: 24179170
    10. these findings indicate that cortical EGF levels decrease with a high-salt diet in salt-sensitive rats, promoting ENaC-mediated Na(+) reabsorption in the collecting duct and the development of hypertension. PMID: 23599382
    11. Mineralocorticoid receptors/epithelial Na(+) channels in the choroid plexus are involved in hypertensive mechanisms in stroke-prone spontaneously hypertensive rats. PMID: 23096235
    12. analysis of inhibition of neuronal degenerin/epithelial Na+ channels by the multiple sclerosis drug 4-aminopyridine PMID: 23404498
    13. Myogenic responses are inhibited in posterior cerebral arteries that are transfected with betaENaC and gammaENaC small interfering RNA. PMID: 22090066
    14. Demonstrate that the metalloprotease meprin beta and gamma-ENaC associate directly through cytoplasmic domains. PMID: 20953144
    15. High dietary potassium enhances the inhibitory effect of arachidonic acid and 11,12-epoxyeicosatrienoic acid on ENaC by increasing cytochrome P450 epoxygenase activity and decreasing soluble epoxide hydrolase activity, respectively. PMID: 20595684
    16. Rac1-mediated NOX2 activity is an important component in O(2)(-) regulation of ENaC. PMID: 20097736
    17. The absence of stimulation of ENaCalpha mRNA expression in collecting ducts suggests the physiological significance of ENaCbeta and gamma mRNA for acute regulation by vasopressin PMID: 14567502
    18. the increased or sustained expression of ENaC subunits combined with increased apical targeting in the distal tubule, connecting tubule, and collecting duct are likely to play a role in the sodium retention associated with PAN-induced nephrotic syndrome. PMID: 15075188
    19. rapid inhibition of ENaC and formation of edema when the virus first attaches to the alveolar epithelium might facilitate subsequent influenza infection and may exacerbate alveolar flooding that can lead to acute respiratory failure and death. PMID: 15121635
    20. ANP induced an increase in apical targeting of AQP2 and ENaC.This targeting of ENaC and AQP2 likely represents direct or compensatory effects to increase sodium and water reabsorption and to prevent volume depletion in response to prolonged ANP infusion. PMID: 16174867
    21. Apical targeting of ENaC subunits may contribute to sodium retention associated with HgCl(2)-induced nephrotic syndrome. PMID: 16189294
    22. Increased apical targeting of ENaC subunits combined with diminished abundance of type 2 11beta-hydroxysteroid dehydrogenase in the kidney affects the sodium stage of liver cirrhosis. PMID: 16192424
    23. Puromycin aminonucleoside (PAN) treatment in the absence of aldosterone induced sodium retention, increased ENaC expression, but did not change the subcellular distribution of ENaC. PMID: 16403831
    24. ENaC and SGK1 are abnormally regulated by aldosterone in salt-sensitive hypertensive rats, suggesting that disturbance of the aldosterone regulation would be one of factors causing salt-sensitive hypertension PMID: 16426574
    25. Aldosterone-induced upregulation of NCC, Sgk1, and ENaC likely contributes to the antinatriuretic phase of metabolic acidosis. This adaptation prevents Na(+) wasting and volume depletion during chronic acid insult. PMID: 16495212
    26. The abundance of the 90-kDa form of the gamma-subunit decreased on salt-restriction, whereas that of a 70-kDa form increased and this peptide exhibited Endo H-resistant glycosylation PMID: 16554417
    27. Finally, the whole kidney abundances of alpha-1 Na-K-ATPase, alpha- beta-, and gamma-ENaC (70-kDa band) positively correlated with net sodium balance, whereas NKCC2 was negatively correlated to FE(Na). PMID: 16757903
    28. These data indicate that expression of ENaC proteins is required for normal VSMC migration and suggest a potential new role for ENaC proteins in vascular tissue repair. PMID: 16844921
    29. Long-term regulation of ENaC and CFTR expression by K(+) channel activity could benefit patients with pulmonary diseases affecting ion transport and fluid clearance. PMID: 16891388
    30. At birth increased Po(2) acts with glucocorticosteroid through an mTOR-related pathway to increase alpha-ENaC protein synthesis, thereby promoting lung fluid absorption. PMID: 17556672
    31. The results support a tetrameric arrangement of epithelial sodium channel subunits where 2alpha, 1beta, and 1gamma come together around central pore. PMID: 17562820
    32. ENaC gamma is functionally related to regulatory volume increase and hypertonicity-induced cation channel activation in rat hepatocytes PMID: 17926064
    33. Cross talk between mitogen-activated protein kinase signaling pathways via the activation of CREB appears to contribute to increased levels of alpha-ENaC. PMID: 17960568
    34. Dietary sodium chloride reduced Scnn1g expression in vascular smooth muscle cells. PMID: 18024548
    35. In CD, macroscopically noninflamed colon contributes to diarrhea via impaired ENaC-mediated sodium absorption. Inhibition of extracellular signal-regulated kinase might serve as a potential therapeutic strategy for CD diarrhea. PMID: 18355814
    36. findings refute the premise that ENaC plays a significant role in the rat afferent arteriole and instead suggest that reducing [Na+](o) and/or Na+ entry is coupled to membrane depolarization. PMID: 18495800
    37. Plasmin in nephrotic urine activates the epithelial sodium channel PMID: 19073825
    38. Altered renal expression of Scnn1g in protein-deprived rats. PMID: 19202345
    39. inappropriate expression and activation of ENaC could be one of the underlying mechanisms by which Dahl salt-sensitive rats develop salt-sensitive hypertension and organ damage. PMID: 19458538
    40. Both ENaC and Na(+)-K(+)-ATPase regulate Na(+) transport in the choroid plexus. PMID: 19635991
    41. The protein abundance of alpha-epithelial sodium channel (alpha-ENaC) was increased while beta-ENaC and gamma-ENaC expression was decreased in the cortex and outer stripe of the outer medulla in heart failure. PMID: 19776175

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  • 亞細胞定位：
    Apical cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Amiloride-sensitive sodium channel (TC 1.A.6) family, SCNN1G subfamily
  • 數(shù)據(jù)庫鏈接：