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  4. Recombinant Rat E3 ubiquitin-protein ligase TRIM50 (Trim50)

Recombinant Rat E3 ubiquitin-protein ligase TRIM50 (Trim50)

  • 中文名稱：
    大鼠Trim50重組蛋白
  • 貨號(hào)：
    CSB-YP802270RA
  • 規(guī)格：
  • 來(lái)源：
    Yeast
  • 其他：
  • 中文名稱：
    大鼠Trim50重組蛋白
  • 貨號(hào)：
    CSB-EP802270RA
  • 規(guī)格：
  • 來(lái)源：
    E.coli
  • 其他：
  • 中文名稱：
    大鼠Trim50重組蛋白
  • 貨號(hào)：
    CSB-EP802270RA-B
  • 規(guī)格：
  • 來(lái)源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    大鼠Trim50重組蛋白
  • 貨號(hào)：
    CSB-BP802270RA
  • 規(guī)格：
  • 來(lái)源：
    Baculovirus
  • 其他：
  • 中文名稱：
    大鼠Trim50重組蛋白
  • 貨號(hào)：
    CSB-MP802270RA
  • 規(guī)格：
  • 來(lái)源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Trim50
  • Uniprot No.：
  • 別名：
    Trim50; E3 ubiquitin-protein ligase TRIM50; EC 2.3.2.27; RING-type E3 ubiquitin transferase TRIM50; Tripartite motif-containing protein 50
  • 種屬：
    Rattus norvegicus (Rat)
  • 蛋白長(zhǎng)度：
    full length protein
  • 表達(dá)區(qū)域：
    1-483
  • 氨基酸序列
    MAWQLTVPEL QDQLQCPICL EVFKEPLMLQ CGHSYCKNCL DSLSEHLDSE LRCPVCRQSV DCSSSPPNVS LARVIDALRL PGDTEPTVCV HHRNPLSLFC EKDQEFICGL CGLLGSHQHH RVTPVSTVYS RMKEELAGRL SELKEQHRDV EEHIGKLVNN RTRIINESDV FSWVIRREFQ ELHHLVDEEK ARCLEGVESH TRGLVASLDM QLEQAQGTQE RLAQAERVLE QFGNESHHEF IRFHSITSRG EVQQARPLEG VFSPISFKPA LHQADIKLTV WKRLFRKVLP APESLKLDPA TAHPLLELSK GNTVVHCGLL AQRRASQPER FDYSTCVLAS KGFSWGRHYW EVVVGSKSDW RLGVIKGTAS RKGKLSKSPE HGVWLIGLKE GRLYEAFGCP RLPLPVAGHP HRIGVYLHYE QGELTFFDAD RPDDLRALYT FQADFQGKLY PILDTCWHER GSNSLPMVLP PPSAPGHLTR AQV
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲(chǔ)存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    E3 ubiquitin-protein ligase that ubiquitinates Beclin-1/BECN1 in a 'Lys-63'-dependent manner enhancing its binding to ULK1. In turn, promotes starvation-induced autophagy activation. Interacts also with p62/SQSTM1 protein and thereby induces the formation and the autophagy clearance of aggresome-associated polyubiquitinated proteins through HDAC6 interaction.
  • 基因功能參考文獻(xiàn)：
    1. TRIM50 protein regulates vesicular trafficking for acid secretion in gastric parietal cells PMID: 22872646
  • 亞細(xì)胞定位：
    Cytoplasm.
  • 蛋白家族：
    TRIM/RBCC family
  • 數(shù)據(jù)庫(kù)鏈接：

    KEGG: rno:288596

    UniGene: Rn.43040