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  4. Recombinant Rat Myosin-7 (Myh7), partial

Recombinant Rat Myosin-7 (Myh7), partial

  • 中文名稱：
    大鼠Myh7重組蛋白
  • 貨號(hào)：
    CSB-YP015300RA
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    大鼠Myh7重組蛋白
  • 貨號(hào)：
    CSB-EP015300RA
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    大鼠Myh7重組蛋白
  • 貨號(hào)：
    CSB-EP015300RA-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    大鼠Myh7重組蛋白
  • 貨號(hào)：
    CSB-BP015300RA
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    大鼠Myh7重組蛋白
  • 貨號(hào)：
    CSB-MP015300RA
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Myh7
  • Uniprot No.：
  • 別名：
    Myh7; Myosin-7; Myosin heavy chain 7; Myosin heavy chain slow isoform; MyHC-slow; Myosin heavy chain; cardiac muscle beta isoform; MyHC-beta
  • 種屬：
    Rattus norvegicus (Rat)
  • 蛋白長度：
    Partial
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲(chǔ)存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle.
  • 基因功能參考文獻(xiàn)：
    1. results suggest that the betae3 site functions as a putative functional overload responsive element in the rat beta-MHC gene promoter PMID: 11832337
    2. higher levels of MHC-beta and dephosphorylated phospholamban may contribute to more contractile dysfunction in male than in female diabetic rat hearts PMID: 12933346
    3. findings suggest that the increased relative expression of MHC-beta is a compensation to sustain cardiac contractile efficiency in response to impaired oxidative metabolism in the hypoxia-induced hypertrophied ventricles PMID: 12941647
    4. cross-bridge cycling, under high strain, for alpha-MHC is three times higher than for beta-MHC. PMID: 15471982
    5. T3 treatment in hypothyroid animals caused beta-MHC mRNA to decline more rapidly than beta-MHC hnRNA, demonstrating, for the first time, a posttranscriptional mechanism(s). PMID: 15650152
    6. Bmyo cardiac myocytes were more responsive to changes in sarcomere length and lattice spacing. PMID: 17347271
    7. Beta-myosin heavy chain is a negative inotrope among the cardiac myofilament proteins. PMID: 17363698
    8. Exercise during chemical gonadectomy provided protection against hypogonadism-induced cardiac dysfunction by preserving myosin heavy chain distribution. PMID: 17906105
    9. Among 19 selected miRNAs, miR-27a was found to most strongly upregulate the beta-myosin heavy chain gene. PMID: 21149577
    10. visual stimulation may play a role in the signals that regulate both nmMyH IIB and EO-MyHC developmental transitions PMID: 21372011
    11. Myocardial stiffness in a rat model of diabetes is studied. Short-range force, a cross-bridge based property, is increased in diabetic hearts. An increase in beta myosin heavy chain isoform expression is the likely mechanism. PMID: 24012810
    12. Cardiomyopathy mutations in the tail of beta-cardiac myosin modify the coiled-coil structure and affect integration into thick filaments in muscle sarcomeres in adult cardiomyocytes. PMID: 24047955
    13. results indicate that T3-bound TRs interfere with transactivation by TEADs via protein-protein interactions, resulting in the negative regulation of MYH7 promoter activity PMID: 24781449
    14. Expression of smooth muscle MyHC B in blood vessels of hypertrophied heart in experimentally hypertensive rats PMID: 12529291
    15. Data show that reactive oxygen species mediate endothelin-1-induced activation of mitogen-activated protein kinase pathways, which culminates in hypertrophic responses and beta-myosin heavy chain expression. PMID: 15864745

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  • 亞細(xì)胞定位：
    Cytoplasm, myofibril. Cytoplasm, myofibril, sarcomere.
  • 蛋白家族：
    TRAFAC class myosin-kinesin ATPase superfamily, Myosin family
  • 數(shù)據(jù)庫鏈接：