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Recombinant Rat Neurotrophin-3 (Ntf3)

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  • 中文名稱：
    大鼠Ntf3重組蛋白
  • 貨號：
    CSB-EP016120RA
  • 規(guī)格：
    ￥1836
  • 圖片：
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他：

產(chǎn)品詳情

  • 純度：
    Greater than 85% as determined by SDS-PAGE.
  • 基因名：
  • Uniprot No.：
  • 別名：
    (NT-3)(HDNF)(Nerve growth factor 2)(NGF-2)(Neurotrophic factor)
  • 種屬：
    Rattus norvegicus (Rat)
  • 蛋白長度：
    Full Length of Mature Protein
  • 來源：
    E.coli
  • 分子量：
    21.1 kDa
  • 表達區(qū)域：
    140-258aa
  • 氨基酸序列
    YAEHKSHRGEYSVCDSESLWVTDKSSAIDIRGHQVTVLGEIKTGNSPVKQYFYETRCKEARPVKNGCRGIDDKHWNSQCKTSQTYVRALTSENNKLVGWRWIRIDTSCVCALSRKIGRT
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白標簽：
    N-terminal 10xHis-tagged and C-terminal Myc-tagged
  • 產(chǎn)品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液：
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    3-7 business days
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    Seems to promote the survival of visceral and proprioceptive sensory neurons.
  • 基因功能參考文獻：
    1. the combined delivery of NT-3 and anti-NogoA from the DDS in an impact/compression model of SCI increases axon density and improves locomotor function. PMID: 27056081
    2. Compared to the sham group, the expression levels of NT-3 were significantly decreased and electroacupuncture was shown to upregulate the expression of NT-3 PMID: 27597902
    3. results demonstrate that BDNF and NT3 regulate axon initial segmen location and neuronal excitability PMID: 28440877
    4. Neurotrophin 3 activity in spinal cord was higher in balance and coordination trained animals following sciatic nerve crush compared to endurance trained. PMID: 26316168
    5. The expressed BDNF and NT3 exert a synergistic effect, which may promote the neuronal differentiation of adiposederived stem cells. PMID: 26239042
    6. These results indicate the feasibility of fabricating NT-3-immobilized scaffolds using the adsorption of NT-3/SF coating method, as well as the potential of these scaffolds to induce SCI repair by promoting survival and neuronal differentiation PMID: 25215612
    7. NT-3 gene-modified bone marrow-derived mesenchymal stem cells via lumbar puncture can strengthen the therapeutic benefits of bone mesenchymal stem cell transplantation PMID: 24744011
    8. A method of hypoglossal-facial nerve anastomosis through an NT3-expressing predegenerated nerve graft engineered by lentiviral vectors is designed to treat complete facial palsy in adult rats. PMID: 23581595
    9. Our results show that NT-3 modifies the ability of the mossy fiber pathway to present subsequent long-term potentiation PMID: 23387385
    10. mRNA expression of brain-derived neurotrophic factor (BDNF) and NT-3 (but not nerve growth factor) in injury segment follows neural stem cell transplantation and is remarkably upregulated. PMID: 22573254
    11. The exposure to long-term stress likely affects a variety of organs capable of releasing NT-3 into the bloodstream. Elevation of plasma NT-3 levels may play important roles in homeostasis under stress conditions. PMID: 23074106
    12. We conclude that upregulation of NT-3 in neonatally wounded skin is a critical factor mediating the sensory nerve sprouting that underlies hypersensitivity and pain following skin injury. PMID: 22871470
    13. Upregulation of neurotrophin-3 in PC12 cells reduces apoptosis under hypoxic conditions. PMID: 22960790
    14. The NTF3 gene promoted differentiation of neural stem cells into cholinergic neurons and enhanced neuronal cell survival PMID: 22971496
    15. Accompanying the simulated weightlessness extension, NT-3 expression in rat soleus muscle spindles is progressively decreased. PMID: 21340438
    16. Transient receptor potential canonical (TRPC)5 acts as a novel and specific mediator for NT-3 to regulate dendrite development through calcium/calmodulin-dependent protein kinase (CaMK)IIalpha. PMID: 22764246
    17. Muscle NT-3 levels increased by exercise training contribute to the improvement in caudal nerve conduction velocity in diabetic rats. PMID: 22552353
    18. Endogenous NT-3 may be involved in the analgesic effect of electroacupuncture on inflammatory pain in rats, mediated through the inhibition of spinal glial activity. PMID: 21680256
    19. Neurotrophin 3 modulates neuropathic pain in the dorsal root ganglia in a rat model. PMID: 21221027
    20. MiR21 is a candidate for regulating neurotrophin-3 signaling in the hippocampus following status epilepticus. PMID: 22019057
    21. neurotrophin 3 signaling pathway is essential for opiate-induced adaptation of locus coeruleus neurons. PMID: 17688944
    22. NT-3 immunoreactivity increased in activated fibers after partial transection of facial nerve. PMID: 21473141
    23. Neurotrophin 3 may lead to enhanced exocytosis of synaptic vesicles. PMID: 21370927
    24. regular rhythms of BDNF and NT-3 are essential for correct cortical network formation in juvenile rodents PMID: 21527636
    25. regrowth and perception were improved when the nerve graft overexpressed neurotrophin-3 at the time of transplantation PMID: 21135740
    26. Endogenous NT-3 has a distinctive role in promoting spiral ganglion axon growth in the organ of Corti and synaptogenesis on inner hair cells. PMID: 21613508
    27. Results suggest that proneurotrophin-3 and proBDNF may play important roles in the response to noise-induced injuries or ototoxic damage via the Sortilin:p75(NTR) death-signalling complex. PMID: 21261755
    28. 3'UTR of calreticulin has two conserved regions, and either of these is sufficient for axonal and dendritic targeting; only nucleotides 1315-1412 show ligand responsiveness to neurotrophin 3 (NT3) and myelin-associated glycoprotein (MAG) PMID: 20308067
    29. Report the proangiogenic capacity of NT-3 and propose NT-3 as a novel potential agent for the treatment of ischemic disease. PMID: 20360537
    30. Our results indicate for the first time that monoaminergic neurotransmitters play an important role in the regulation of NT-3 synthesis in cultured rat astrocytes. PMID: 19854260
    31. Brain-derived neurotrophic factor (BDNF) levels in the spinal cord, as detected by enzyme-linked immunosorbent assay, decreased with time, whereas neurotrophin-3 (NT-3) levels remained unchanged. PMID: 19203225
    32. exercise decreases hippocampal neurotrophin-3 PMID: 12914971
    33. ability of neurotrophin-3 (NT-3) to prevent abnormalities in neurofilamens in sensory neurons in experimental diabetes PMID: 12941778
    34. neurotrophin-3 (NT-3), delivered chronically via fibroblasts implanted intrathecally into neonatal rats, can facilitate synaptic transmission in the spinal cord PMID: 14507970
    35. Transfection of NT-3 into oligidendrocyte precursors caused a 10-fold increase in myelin basic protein production observed in myelin membranes in cocultures with hippocampal neurons. PMID: 15139015
    36. the level of supraspinal and muscle afferent input plays an important role in modulating the levels of BDNF and NT-3 in the spinal cord. PMID: 15548637
    37. These data demonstrate that localized overexpression of BDNF or NT-3, but not NGF, is sufficient to promote sprouting of serotonergic axons in the cortex following an experimental neurotoxic injury. PMID: 16206279
    38. BDNF, NT-3, and NGF, secreted by transplanted neural stem cells, were involved in the promotion of corticospinal axon growth after transplantation PMID: 17515814
    39. Glutamate receptor blockade inhibited the generation of spontaneous sodium-driven action potentials which, in turn, regulate both the endogenous secretion of NT-3 and the calbindin-D(28k) phenotype acquisition. PMID: 17561837
    40. neurotrophin-3 is a unique hypertrophic factor, which is paradoxically downregulated in cardiac hypertrophy and might counteract hypertrophic change PMID: 17628607
    41. Biochemically, the XYS decoction also reversed CIS-induced decreases in BDNF and increases in TrkB and NT-3 in the frontal cortex and the hippocampal CA(1) subregion. PMID: 17647101
    42. Vascular-derived NT-3 increases or maintains neuropeptide Y and tyrosine hydroxylase expression in postganglionic sympathetic neurons PMID: 18032527
    43. The functional consequences of the effect of IL-1beta on NT-3 signaling were severe, as NT-3 protection of the trophic support-deprived cortical neurons was abrogated. PMID: 18036576
    44. Increased NT-3 mRNA expression in hippocampus was detected in the immobilization stress group; the magnitude of increase in NT-3 mRNA was decreased when animals were allowed to bite. PMID: 18191115
    45. Co-culture of Ntf3 over-expressing Schwann cells with SGNs from early postnatal rats significantly enhanced neuronal survival in comparison to both control Schwann cells and conventional recombinant neurotrophin proteins. PMID: 18304740
    46. Non-viral vector-mediated genetic engineering of OEG was safe and more effective in producing NT-3 and promoting axonal outgrowth followed by enhancing SCI recovery in rats. PMID: 18369383
    47. Exposure of neurons to increased levels of NT-3 reduces expression of sodium channels Na(v)1.8 and Na(v)1.9 in dorsal root ganglia neurons subject to chronic constriction injury. PMID: 18601922
    48. levels in cerebellar vermis were higher for animals in an enriched environment after prenatal alcohol exposure PMID: 18652597
    49. Analysis of neurotrophin expression in dentate gyrus dosen't reveal an expression change of Ntf3 in a genetically hypertensive strain of Wistar rat. PMID: 18957307
    50. findings suggest that orexins, but not melanin-concentrating hormone, may be an inducer of NT-3 in the cerebral cortex PMID: 19026718

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  • 亞細胞定位：
    Secreted.
  • 蛋白家族：
    NGF-beta family
  • 組織特異性：
    Brain and peripheral tissues.
  • 數(shù)據(jù)庫鏈接：