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  4. Recombinant Rat Transient receptor potential cation channel subfamily V member 1 (Trpv1), partial

Recombinant Rat Transient receptor potential cation channel subfamily V member 1 (Trpv1), partial

  • 中文名稱：
    大鼠Trpv1重組蛋白
  • 貨號：
    CSB-YP025093RA
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    大鼠Trpv1重組蛋白
  • 貨號：
    CSB-EP025093RA
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    大鼠Trpv1重組蛋白
  • 貨號：
    CSB-EP025093RA-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    大鼠Trpv1重組蛋白
  • 貨號：
    CSB-BP025093RA
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    大鼠Trpv1重組蛋白
  • 貨號：
    CSB-MP025093RA
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    Trpv1; Vr1; Vr1l; Transient receptor potential cation channel subfamily V member 1; TrpV1; Capsaicin receptor; Osm-9-like TRP channel 1; OTRPC1; Vanilloid receptor 1; Vanilloid receptor type 1-like
  • 種屬：
    Rattus norvegicus (Rat)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    Ligand-activated non-selective calcium permeant cation channel involved in detection of noxious chemical and thermal stimuli. Seems to mediate proton influx and may be involved in intracellular acidosis in nociceptive neurons. Involved in mediation of inflammatory pain and hyperalgesia. Sensitized by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases, which involves PKC isozymes and PCL. Activation by vanilloids, like capsaicin, and temperatures higher than 42 degrees Celsius, exhibits a time- and Ca(2+)-dependent outward rectification, followed by a long-lasting refractory state. Mild extracellular acidic pH (6.5) potentiates channel activation by noxious heat and vanilloids, whereas acidic conditions (pH <6) directly activate the channel. Can be activated by endogenous compounds, including 12-hydroperoxytetraenoic acid and bradykinin. Acts as ionotropic endocannabinoid receptor with central neuromodulatory effects. Triggers a form of long-term depression (TRPV1-LTD) mediated by the endocannabinoid anandamine in the hippocampus and nucleus accumbens by affecting AMPA receptors endocytosis.; Does not display channel activity in response to noxious chemical compounds, such as capsaicin and the vanilloid resiniferatoxin. Channel activity is not elicited by mildly acidic extracellular pH, and only slight channel activity is observed in response to noxiuos heat stimuli.
  • 基因功能參考文獻：
    1. Findings demonstrated that activation of TRPV1 receptor by capsaicin improved memory decline and increased mRNA expression of the TRPV1 and CREB in the hippocampus of rats with biliary cirrhosis. A positive association was also found between mRNA expression of TRPV1 and CREB, and between memory function and TRPV1 expression. Overall, this study supports the idea that TRPV1 receptor can regulate learning and memory process PMID: 30079821
    2. Pain thresholds of diabetic rats increased significantly compared with control. Expression of TRPV1 receptors in dorsal root ganglia (DRG) substantially decreased. Relative levels of TNF-alpha and IL-1beta in the serum of lncRNA BC168687 siRNA-treated rats were reduced. Phosphorylation (p)-ERK and p-p38 signaling pathways in DRG were also decreased. PMID: 29421435
    3. Activation of TRPV1 plays an anti-inflammatory and anti-oxidative stress role in preventing renal tissue damage and salt-induced hypertension after renal I/R injury PMID: 30078015
    4. present findings suggest that the excitability of TG neurons is enhanced upon tooth pulp inflammation, leading to overexpression of TRPV1 in TG neurons innervating the facial skin, and that satellite glial cells are also activated, resulting in the development of ectopic orofacial pain PMID: 29479030
    5. An increase in TRPV1 levels was observed in CGRP-incubated TG organ cultures. PMID: 28205139
    6. Transplantation of recombinant NSCs with vascular endothelial growth factor (VEGF) might promote neuronal repair. This effect might be attributed to the reduced transient receptor potential vanilloid 1 (TRPV1) expression following transplantation. PMID: 29466323
    7. Testosterone level affects TRPV1 mRNA and protein expression in trigeminal ganglia. PMID: 29209900
    8. Findings indicate functional interactions of the nociceptive ion channel transient receptor potential vanilloid type 1 receptor (TRPV1) and the insulin receptor (InsR). PMID: 29215540
    9. Increased CaSR and TRPC6 expression in CDH lung suggests that CaSR interacting with TRPC6 may contribute to abnormal vascular remodeling resulting in pulmonary vasoconstriction and development of PPH. PMID: 28983729
    10. Data (including data from studies in mutant mice and knockout mice) suggest that dietary basic amino acids L-ornithine and L-lysine stimulate gastrointestinal motility via activation of Trpv1 in small intestine; dietary L-arginine suppresses gastrointestinal motility. PMID: 28722259
    11. Remote hind limb preconditioning stimulus probably activates TRPV1 channels which subsequently induces CGRP release to produce cardioprotective effects. PMID: 28599085
    12. the current results are the first to demonstrate the molecular level effects of Dexmedetomidine (DEX) on TRPM2 and TRPV1 activation. Therefore, DEX can have remarkable neuroprotective impairment effects in the hippocampus and DRG of cerebral ischemia-induced rats. PMID: 27872485
    13. data demonstrate that lactate at physiologically relevant concentrations is a potent endogenous inhibitor of TRPV1. PMID: 27827430
    14. Results suggest that facial heat hyperalgesia in diabetic rats is maintained by peripheral and central TRPV1 receptors activation. PMID: 28606782
    15. TRPV1 expressed in dorsal root ganglia may serve an important role in endometriosis-associated pain. PMID: 28627595
    16. The presence of regulation of TRPV1 channel activity by TRPA1 channels in dorsal ganglion neurons has been demonstrated. PMID: 29537196
    17. H2S regulated blood pressure via an increase in TRPV1 protein expression and its activity to enhance carotid sinus baroreceptor sensitivity. PMID: 28512115
    18. results suggest that noradrenaline directly acts on dorsal root ganglion neurons to inhibit the activity of TRPV1 depending on the activation of alpha2-adrenoceptors followed by the inhibition of the adenylate cyclase/cAMP/protein kinase A pathway PMID: 29304162
    19. It could be activated by hyperglycemiainduced inflammatory reaction. PMID: 29121795
    20. These data indicate that excitability of sacral dorsal commissural nucleus neurons undergoes a developmental shift, and these neurons receive functional TRPV1 terminals from early postnatal stage. PMID: 26526845
    21. Results suggest the involvement of TRPV1 in allergic asthma. PMID: 27255083
    22. Stimulation of TRPV1 receptors augments TRPA1 responses of DRG neurons to a greater degree after femoral artery occlusion, indicating that TRPV1 is partly responsible for augmented TRPA1 responses. PMID: 28848196
    23. Advanced oxidation protein products increased significantly in Freund's adjuvant-induced hyperalgesia rats and they activated Nox1/Nox4-reactive oxygen species to sensitize TRPV1-dependent Ca2+ influx and CGRP release which led to inducing mechanical hyperalgesia. PMID: 27665186
    24. The results of this study showed that TRPV1 receptors might be implicated in both unimodal and cross-modal encoding of information in an object recognition task in rats. PMID: 28359919
    25. Systemic resiniferatoxin administration (20 mug/kg body weight daily for 3 days), which was previously demonstrated to eliminating all TRPV1-expressing sensory neurons, did not affect the expression pattern of TRPV1 in the prostate epithelium. PMID: 27180305
    26. The effects of capsaicin were partially blocked by TRPV1 antagonists. PMID: 27900462
    27. Transient receptor potential vanilloid 1 (TRPV1) and cannabinoid 1 (CB1) receptors of the midbrain and medulla are colocalized modulators of pain. PMID: 28542001
    28. When cancer cells metastasized into bone marrow, the elevated endogenous formaldehyde induced bone cancer pain through TRPV1 activation in the peripheral nerve fibers. TRPV1 expression in these fibers was upregulated by the local IGF-I produced by the activated osteoblasts. Review. PMID: 26900062
    29. Analgesic effect of coumarins from Radix angelicae pubescentis is mediated by inflammatory factors/TRPV1 pathway in model of neuropathic pain. PMID: 27915078
    30. Finally, both treatments stimulated thirst; however, cumulative water intakes in response to hypernatremia or hypotension were not different between control and TRPV1(-/-) rats. These findings suggest that TRPV1 channels are not necessary for VP secretion and thirst stimulated by hypernatremia. PMID: 27335281
    31. Transient receptor potential vanilloid type 1 (TRPV1) both in the parodontium and trigeminal ganglion are involved in orthodontic pain, and TRPV1 in the parodontium influence on orthodontic pain through reducing the expression of TRPV1 in trigeminal ganglion. PMID: 27267133
    32. activation of T2Rs augments capsaicin-evoked TRPV1 responses in rat pulmonary nociceptors through the phospholipase C and protein kinase C signaling pathway. PMID: 28062485
    33. Study suggests that TRPV1 activation tonically potentiates rostroventromedial medulla-mediated descending antinociception during diabetic neuropathic pain, a phenomenon that seems not to occur in physiological conditions, and imply the occurrence of diabetic neuropathic pain-specific changes in rostroventromedial medulla TRPV1-mediated neurotransmission PMID: 26965218
    34. The TRPV1 activation significantly decreased the activity of PI3K and phosphorylation level of Akt in SHR-derived contractile vascular smooth muscle cells (VSMCs). PMID: 27774580
    35. Inferior alveolar nerve injury did not change the expression of GluA1, GluA2 and CGRP, but increased the expression of TRPV1 and SP. PMID: 28337884
    36. Study showed that the activity of TRPV1 was enhanced in facilitating glutamate release during morphine withdrawal, and capsazepine could fully reverse this effect without changing the basal glutamatergic neurotransmission in nucleus accumbens. PMID: 28188777
    37. Increased colon H2O2 content in trinitrobenzene sulfate-induced colitis may contribute to the visceral hyperalgesia by activating TRPA1. PMID: 26574143
    38. TRPV1 channels limit the vasomotor responses to changes in pH. While base-induced arterial contraction is regulated primarily by neural TRPV1 channels, acid-induced arterial relaxation is modulated by TRPV1 channels located on nonneural vascular structures. PMID: 27923234
    39. Our results suggest that a possible relationship between xanthine oxidase-related reactive oxygen species and TRPV1 may exist during the events preceding eccentric exercise PMID: 26987748
    40. The use of intranasal administration of the APHC3 peptide as a therapeutic approach aimed at decreasing depression symptoms needs additional studies in order to find the mechanism of action of this polypeptide in the central nervous system (CNS). PMID: 27822750
    41. VR1 mediates bone marrow mesenchymal stem cell differentiation to cardiomyocyte-like cells via Wnt/beta-catenin signaling pathway. PMID: 27662603
    42. Adenosine contributes to muscle afferent TRPV1-engaged reflex sympathetic and pressor responses. PMID: 27842306
    43. Electroacupuncture at ST25 was found to inhibit jejunal motility in an intensity-dependent manner, via a mechanism in which sympathetic nerves and TRPV1 receptors play an important role. PMID: 26855542
    44. The tarantula double-knot toxin binds to the outer edge of the external pore of TRPV1 in a counterclockwise configuration, using a limited protein-protein interface and inserting hydrophobic residues into the bilayer. PMID: 26880553
    45. Results suggest that systemic administration of TRPV1-active drugs influences electrically induced epilepsy, with a noticeable protective activity for capsazepine, possibly through a CB1-dependent mechanism PMID: 26970948
    46. a high concentration of calcium in seawater exacerbated lung injury, and TRPV1 channels were notable mediators of the calcium increase initiated by the seawater challenge. PMID: 26796050
    47. spinal cord TRPV1 and TRPA1 contributes to pain after burn PMID: 27411353
    48. enhancement by TNFalpha of Ca(2+) influx through the upregulated surface-expressed TRPV1 and TRPA1 channels was abolished by BoNT/A. PMID: 26888187
    49. The behavioral and molecular data indicated that TRPV1 is strongly modulated by Cdk5-mediated phosphorylation at position threonine-407(mouse)/threonine406(rat). PMID: 26902776
    50. Tyr(511)-mediated anchoring of vanilloids in their binding pocket is pivotal for TRPV1 activation and subsequent pain sensation. PMID: 27143360

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  • 亞細胞定位：
    Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell projection, dendritic spine membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Transient receptor (TC 1.A.4) family, TrpV subfamily, TRPV1 sub-subfamily
  • 組織特異性：
    Predominantly expressed in trigeminal and dorsal root sensory ganglia. Expressed also in hippocampus, cortex, cerebellum, olfactory bulb, mesencephalon and hindbrain. High expression in the cell bodies and dendrites of neurons in the hippocampus and in th
  • 數(shù)據(jù)庫鏈接：