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  4. Recombinant Saccharomyces cerevisiae DNA mismatch repair protein PMS1 (PMS1), partial

Recombinant Saccharomyces cerevisiae DNA mismatch repair protein PMS1 (PMS1), partial

  • 中文名稱：
    釀酒酵母PMS1重組蛋白
  • 貨號(hào)：
    CSB-YP320344SVG
  • 規(guī)格：
  • 來(lái)源：
    Yeast
  • 其他：
  • 中文名稱：
    釀酒酵母PMS1重組蛋白
  • 貨號(hào)：
    CSB-EP320344SVG
  • 規(guī)格：
  • 來(lái)源：
    E.coli
  • 其他：
  • 中文名稱：
    釀酒酵母PMS1重組蛋白
  • 貨號(hào)：
    CSB-EP320344SVG-B
  • 規(guī)格：
  • 來(lái)源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    釀酒酵母PMS1重組蛋白
  • 貨號(hào)：
    CSB-BP320344SVG
  • 規(guī)格：
  • 來(lái)源：
    Baculovirus
  • 其他：
  • 中文名稱：
    釀酒酵母PMS1重組蛋白
  • 貨號(hào)：
    CSB-MP320344SVG
  • 規(guī)格：
  • 來(lái)源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    PMS1
  • Uniprot No.：
  • 別名：
    PMS1; YNL082W; N2317; DNA mismatch repair protein PMS1; Postmeiotic segregation protein 1
  • 種屬：
    Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
  • 蛋白長(zhǎng)度：
    Partial
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲(chǔ)存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Required for DNA mismatch repair (MMR), correcting base-base mismatches and insertion-deletion loops (IDLs) resulting from DNA replication, DNA damage or from recombination events between non-identical sequences during meiosis. Component of the MutLalpha heterodimer that forms a ternary complex with the MutS heterodimers, which initially recognize the DNA mismatches. This complex is thought to be responsible for directing the downsteam MMR events, including strand discrimination, excision, and resynthesis. Plays a major role in maintaining the genetic stability of simple sequence repeats and in the repair of heteroduplex sites present in meiotic recombination intermediates.
  • 基因功能參考文獻(xiàn)：
    1. Two mutants of MutLalpha, pms1-G882E and pms1-H888R, repair deletion mispairs but not insertion mispairs. PMID: 24204320
    2. The unstructured linker arms of Mlh1-Pms1 are important for interactions with DNA during mismatch repair PMID: 22659005
    3. Functional residues on the surface of the N-terminal domain of yeast Pms1 PMID: 20138591
    4. Suggested that the inherent inefficiency of primer strand loop repair involves Pms1 that functions downstream of mismatch recognition. The findings reinforce the current view that during mutation avoidance, MMR is associated with the replication apparatus PMID: 16227575
  • 亞細(xì)胞定位：
    Nucleus.
  • 蛋白家族：
    DNA mismatch repair MutL/HexB family
  • 數(shù)據(jù)庫(kù)鏈接：

    KEGG: sce:YNL082W

    STRING: 4932.YNL082W