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  4. Recombinant Saccharomyces cerevisiae G1/S-specific cyclin CLN3 (CLN3), partial

Recombinant Saccharomyces cerevisiae G1/S-specific cyclin CLN3 (CLN3), partial

  • 中文名稱：
    Recombinant Saccharomyces cerevisiae G1/S-specific cyclin CLN3(CLN3) ,partial,Yeast
  • 貨號：
    CSB-YP318356SVG
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Saccharomyces cerevisiae G1/S-specific cyclin CLN3(CLN3) ,partial,Yeast
  • 貨號：
    CSB-EP318356SVG
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Saccharomyces cerevisiae G1/S-specific cyclin CLN3(CLN3) ,partial,Yeast
  • 貨號：
    CSB-EP318356SVG-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Saccharomyces cerevisiae G1/S-specific cyclin CLN3(CLN3) ,partial,Yeast
  • 貨號：
    CSB-BP318356SVG
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Saccharomyces cerevisiae G1/S-specific cyclin CLN3(CLN3) ,partial,Yeast
  • 貨號：
    CSB-MP318356SVG
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    CLN3
  • Uniprot No.：
  • 別名：
    CLN3; DAF1; WHI1; YAL040C; FUN10; G1/S-specific cyclin CLN3
  • 種屬：
    Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
  • 蛋白長度：
    Partial
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價(jià)

靶點(diǎn)詳情

  • 功能：
    Essential for the control of the cell cycle at the G1/S (start) transition. CLN3 may be an upstream activator of the G1 cyclins which directly catalyze start.
  • 基因功能參考文獻(xiàn)：
    1. G0/G1 transition, via Rim 15 and CLN3, might govern the fermentation rate of bottom-fermenting brewer's yeast in high-gravity wort. PMID: 27212268
    2. Whi5 phosphorylation by Cln3-Cdk1 embedded in the G1/S network dynamically controls critical cell size and cell fate. PMID: 27094800
    3. In CLN3, Whi3 may bind to the 3' GCAU motifs to attract the Ccr4-Not complex to promote RNA deadenylation and turnover, and Whi3 may bind to the 5' GCAU motifs to inhibit translation. PMID: 24386402
    4. T36 phosphorylation triggers displacement of Ydj1, allowing Ssa1 to bind the G1 cyclin Cln3 and promote its degradation; these results establish an active role for Hsp70 chaperones as signal transducers mediating growth control of G1 cyclin abundance and activity PMID: 23217712
    5. The spatial regulation of GAL1 and CLN3 transcripts is what allows growth to be maintained during fluctuations of glucose availability. PMID: 22160690
    6. Cln3 regulates SBF by at least two different pathways, one involving the repressive protein Whi5, and the second involving Stb1 PMID: 19823669
    7. Cln3 must overcome Far1 to trigger Cln-Cdc28 activation, which then turns on transcription; a second threshold is required together with the Cln3/Far1 threshold for carbon source modulation of protein content per cell at the onset of DNA replication PMID: 15520229
    8. HPD(hydrophobic patch domain) of Cln3 identified important for interaction of Cln3 with Cdc28. PMID: 16200502
    9. Cln3 contains a chaperone-regulatory Ji domain that counteracts Ydj1, a J chaperone essential for ER release and nuclear accumulation of Cln3 in late G1. PMID: 17560371
    10. Cln3 activates only G1/S phase genes PMID: 19158491

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  • 蛋白家族：
    Cyclin family
  • 數(shù)據(jù)庫鏈接：

    KEGG: sce:YAL040C

    STRING: 4932.YAL040C