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  4. Recombinant Saccharomyces cerevisiae Protein CGI121 (CGI121)

Recombinant Saccharomyces cerevisiae Protein CGI121 (CGI121)

  • 中文名稱：
    Recombinant Saccharomyces cerevisiae Protein CGI121(CGI121),Yeast
  • 貨號(hào)：
    CSB-YP311813SVG
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Saccharomyces cerevisiae Protein CGI121(CGI121),Yeast
  • 貨號(hào)：
    CSB-EP311813SVG
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Saccharomyces cerevisiae Protein CGI121(CGI121),Yeast
  • 貨號(hào)：
    CSB-EP311813SVG-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Saccharomyces cerevisiae Protein CGI121(CGI121),Yeast
  • 貨號(hào)：
    CSB-BP311813SVG
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Saccharomyces cerevisiae Protein CGI121(CGI121),Yeast
  • 貨號(hào)：
    CSB-MP311813SVG
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    CGI121
  • Uniprot No.：
  • 別名：
    CGI121; YML036WEKC/KEOPS complex subunit CGI121; CGI-121 homolog
  • 種屬：
    Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
  • 蛋白長度：
    full length protein
  • 表達(dá)區(qū)域：
    1-181
  • 氨基酸序列
    MVVSIIPQFP DIKVSLALFE QVKNAKEIRS KMSELSTSFA FIDPRLVCSG EQMYSAIYKT LIEVKYNKMR TRNLNSECVL CLSPTSNISD AFLKFGIKDD SSQLICLKFH TNTDDVDKEQ LRTIMTSIVK GQEIEFNDDN LSRFYDEALI RKIYKLSDDF KPQDVNGLSR ALVDAIQLRG V
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲(chǔ)存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. CGI121 acts as an allosteric effector that regulates the t(6)A activity of the complex. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is required for efficient recruitment of transcriptional coactivators. CGI121 is not required for tRNA modification.
  • 基因功能參考文獻(xiàn)：
    1. Deletion of CGI121 in the short-lived yku80(tel) mutant restores lifespan to cgi121Delta level, supporting the function of Cgi121 in telomeric single-stranded DNA generation and thus in promotion of telomere recombination. PMID: 25822194
    2. Cgi121 is part of the conserved KEOPS protein complex which promotes both telomere uncapping and telomere elongation PMID: 16564010
  • 亞細(xì)胞定位：
    Nucleus. Chromosome, telomere.
  • 蛋白家族：
    CGI121/TPRKB family
  • 數(shù)據(jù)庫鏈接：

    KEGG: sce:YML036W

    STRING: 4932.YML036W