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Recombinant Xenopus laevis BRCA1-A complex subunit Abraxas (fam175a)

  • 中文名稱：
    Recombinant Xenopus laevis BRCA1-A complex subunit Abraxas(fam175a),Yeast
  • 貨號：
    CSB-YP756984XBE
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Xenopus laevis BRCA1-A complex subunit Abraxas(fam175a),Yeast
  • 貨號：
    CSB-EP756984XBE
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Xenopus laevis BRCA1-A complex subunit Abraxas(fam175a),Yeast
  • 貨號：
    CSB-EP756984XBE-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Xenopus laevis BRCA1-A complex subunit Abraxas(fam175a),Yeast
  • 貨號：
    CSB-BP756984XBE
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Xenopus laevis BRCA1-A complex subunit Abraxas(fam175a),Yeast
  • 貨號：
    CSB-MP756984XBE
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    abraxas1
  • Uniprot No.：
  • 別名：
    abraxas1; abra1; ccdc98; fam175aBRCA1-A complex subunit Abraxas 1; Coiled-coil domain-containing protein 98; Protein FAM175A
  • 種屬：
    Xenopus laevis (African clawed frog)
  • 蛋白長度：
    full length protein
  • 表達(dá)區(qū)域：
    1-408
  • 氨基酸序列
    MEGESTTAVI SGFVFGALTF HHLNSGSDTE GFLLGDVMGE AKNSITDSQM DDVEVLYTID IQKHVPCYQL SRFYNALGDL NIPELKKLLA GQKKSQNVIG WYKFRHNTEQ IMTFRERLLH KNLQEHFSNS GLVFLLLTSN PATETKSTHR LEYALHKPQD GFFHKVPLVI SNLGMSDQQG YKTLCGSCVS VGLNTAIKKH RLEFFNEDGA LAEVNRISDM HMTLQEELKK TCSQLVESEN SVEQLLEAVN DLKKQIAEKK LLMEEKGNKV SEDTEENVLL CEAFRRFFPQ SALLQSCRLS LGGRQIPHSC SVSHNSSDVN ELTLMVKQYD FPEAHRRQAG KRKAHSKQLG KTSTKKSRLP PFQRPQSDNS DSESSDSEKL LCTSGTETDG DIVQSLNVEV SRSKSPTF
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    Involved in DNA damage response and double-strand break (DSB) repair. Component of the BRCA1-A complex, acting as a central scaffold protein that assembles the various components of the complex and mediates the recruitment of brca1. The BRCA1-A complex specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesion sites, leading to target the brca1-bard1 heterodimer to sites of DNA damage at DSBs. This complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX.
  • 亞細(xì)胞定位：
    Nucleus.
  • 蛋白家族：
    FAM175 family, Abraxas subfamily
  • 數(shù)據(jù)庫鏈接：

    KEGG: xla:443765

    UniGene: Xl.11518