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Recombinant Bovine P-selectin (SELP)

  • 中文名稱：
    牛SELP重組蛋白
  • 貨號(hào)：
    CSB-CF020978BO
  • 規(guī)格：
  • 來(lái)源：
    in vitro E.coli expression system
  • 其他：

產(chǎn)品詳情

  • 基因名：
  • Uniprot No.：
  • 別名：
    SELP; P-selectin; CD62 antigen-like family member P; Granule membrane protein 140; GMP-140; Leukocyte-endothelial cell adhesion molecule 3; LECAM3; Platelet activation dependent granule-external membrane protein; PADGEM; CD antigen CD62P
  • 種屬：
    Bos taurus (Bovine)
  • 蛋白長(zhǎng)度：
    Full Length of Mature Protein
  • 表達(dá)區(qū)域：
    42-646
  • 氨基酸序列
    WTYHYSNKTYSWNYSRAFCQKYYTDLVAIQNKNEIAYLNETIPYYNSYYWIGIRKINNKWTWVGTKKTLTEEAENWADNEPNNKRNNQDCVEIYIKSLSAPGKWNDEPCWKRKRALCYRASCQDMSCSKQGECIETIGNYTCSCYPGFYGPECEYVRECGEFDLPQHVHMNCSHPLGNFSFNSHCSFHCAEGYALNGPSELECLASGIWTNSPPQCVAVQCPALKSPEQGSMSCVQSAEAFQHQSSCSFSCEEGFALVGPEVVHCTALGVWTAPTPVCKALQCQDLPTSTKARVNCSHPFGDFRYQSTCSFTCDEGSFLVGASVLQCLDTGNWDAPFPECQAVTCAALPNPQNGEKTCVQPLGGSSYESTCWFTCHEGFSLSGPERLDCTPSGHWTGSPPTCEEVDTVSAPAPGVQCPTLIAPKQGTMSCQHHVRNFGLNTTCHFGCKAGFTLLGDSALQCRPSRQWTAAAPTCRAVKCAKLPVTEPIVMNCSNPWGNFSYGSTCSFHCPEGQLLNGSERTVCQENGQWSTTMPTCQAGPLTIQETLTYVGGAAAGTTGLVTGSILLALLRRRCRQKDDGKSPLNPQSHLGTYGVFTNAAFDPSP
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白標(biāo)簽：
    N-terminal 10xHis-tagged
  • 產(chǎn)品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 儲(chǔ)存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Ca(2+)-dependent receptor for myeloid cells that binds to carbohydrates on neutrophils and monocytes. Mediates the interaction of activated endothelial cells or platelets with leukocytes. The ligand recognized is sialyl-Lewis X. Mediates rapid rolling of leukocyte rolling over vascular surfaces during the initial steps in inflammation through interaction with SELPLG.
  • 基因功能參考文獻(xiàn)：
    1. Five single nucleotide polymorphisms (SNPs) from different exons in selectin SELP, two in selectin SELL and one in selectin SELE were taken forward to genotyping in 337 Holstein Friesian heifers using PCR-RFLP. PMID: 28419109
    2. SELP mediates the attachment of peripheral blood leukocytes to endothelium and provides novel evidence that its high polymorphism is likely to affect biological function. This may potentially influence leukocyte migration and fertility, both key to successful performance in dairy cows. PMID: 27663375
  • 亞細(xì)胞定位：
    Cell membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    Selectin/LECAM family
  • 組織特異性：
    Stored in the alpha-granules of platelets and Weibel-Palade bodies of endothelial cells. Upon cell activation by agonists, P-selectin is transported rapidly to the cell surface.
  • 數(shù)據(jù)庫(kù)鏈接：

    KEGG: bta:281486

    UniGene: Bt.4342