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Recombinant Drosophila melanogaster Protein trapped in endoderm-1 (Tre1)

  • 中文名稱：
    黑腹果蠅Tre1重組蛋白
  • 貨號(hào)：
    CSB-CF868252DLU
  • 規(guī)格：
  • 來源：
    in vitro E.coli expression system
  • 其他：

產(chǎn)品詳情

  • 基因名：
    Tre1
  • Uniprot No.：
  • 別名：
    Tre1; CG3171; Protein trapped in endoderm-1
  • 種屬：
    Drosophila melanogaster (Fruit fly)
  • 蛋白長(zhǎng)度：
    full length protein
  • 表達(dá)區(qū)域：
    1-392
  • 氨基酸序列
    MDQDMGMATGYFQDADMQMDEPAAATQSIYPHSATLFAAISACVFVTIGVLGNLITLLAL LKSPTIREHATTAFVISLSISDLLFCSFSLPLTAVRFFQESWTFGTTLCKIFPVIFYGNV AVSLLSMVGITLNRYILIACHSRYSQIYKPKFITLQLLFVWAVSFLLLLPPILGIWGEMG LDEATFSCTILKKEGRSIKKTLFVIGFLLPCLVIIVSYSCIYITVLHQKKKIRNHDNFQI AAAKGSSSSGGGSYMTTTCTRKAREDNRLTVMMVTIFLCFLVCFLPLMLANVVDDERNTS YPWLHIIASVMAWASSVINPIIYAASNRNYRVAYYKIFALLKFWGEPLSPMPSRNYHQSK NSKELSGVIRSTPLFHAVQKNSINQMCQTYSV
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白標(biāo)簽：
    N-terminal 10xHis-tagged
  • 產(chǎn)品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 儲(chǔ)存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Essential for the first active step of germ cell migration: transepithelial migration of germ cells through the posterior midgut (PMG) epithelium.
  • 基因功能參考文獻(xiàn)：
    1. Bifurcation of the Tre1 G protein-coupled receptor signaling response via G protein-dependent and independent branches enables distinct spatiotemporal regulation of germ cell migration. PMID: 28687666
    2. feminizing the Tre1-expressing neurons in male flies leads to rapid courtship initiation, a phenotype that leads to increased reproductive success; Tre1 is expressed in a sexually dimorphic pattern in olfactory sensory neurons and the central nervous system PMID: 26721856
    3. role of the arginine of the NRY motif in Tre1 was investigated; results suggest that a salt bridge may form between this critical arginine and an aspartic acid in transmembrane alpha-helix (TM6)in Tre1 PMID: 24044607
    4. The scattershot allele results in an in-frame deletion of 8 amino acids at the junction of the third transmembrane domain and the second intracellular loop of Tre1 that dramatically impairs the function of this GPCR in germ cell migration. PMID: 20676220
    5. plays an important role in regulation of germ cell migration, polarity , cell adhesion, and cadherin binding. (review) PMID: 20058705
    6. Tre1 is a G protein-coupled receptor that directs transepithelial migration of Drosophila germ cells PMID: 14691551
    7. Down-regulation of E-cadherin causes germ cell dispersal but is not sufficient for transepithelial migration in the absence of Tre1, suggesting a new mechanism for Tre1 GPCR function that links cell polarity, modulation of cell adhesion, and invasion. PMID: 18824569

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  • 亞細(xì)胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    G-protein coupled receptor 1 family
  • 組織特異性：
    In embryos, expression is seen at highest levels in the cuprophilic cells and at lower levels in the amnioserosa, developing CNS, cardiac mesoderm primordium and midline glia.
  • 數(shù)據(jù)庫(kù)鏈接：

    KEGG: dme:Dmel_CG3171

    STRING: 7227.FBpp0070813

    UniGene: Dm.18422