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Recombinant Horse Endothelin B receptor (EDNRB)

  • 中文名稱：
    Recombinant Horse Endothelin B receptor(EDNRB)
  • 貨號(hào)：
    CSB-CF007404HO
  • 規(guī)格：
  • 來(lái)源：
    in vitro E.coli expression system
  • 其他：

產(chǎn)品詳情

  • 基因名：
  • Uniprot No.：
  • 別名：
    EDNRB; Endothelin receptor type B; ET-B; ET-BR; Endothelin receptor non-selective type
  • 種屬：
    Equus caballus (Horse)
  • 蛋白長(zhǎng)度：
    Full Length of Mature Protein
  • 表達(dá)區(qū)域：
    27-443
  • 氨基酸序列
    EERRFPPARATPPLLGFEEIMTPPTKTSWPTGSNASVPRLSAPPQMPKAGRTAGAQRRTL PPPPCERTIEIKETFKYINTVVSCLVFVLGIIGNSTLLRIIYKNKCMRNGPNILIASLAL GDLLHIIIDIPINVYKLLAEDWPFGVEMCKLVPFIQKASVGITVLSLCALSIDRYRAVAS WSRIKGIGVPKWTAVEIVLIWVVSVVLAVPEAVGFDMITADYKGSYLRICLLHPTQKTAF MQFYKNAKDWWLFSFYFCLPLAITAFFYTLETCEMLRKKSGMQIALNDHLKQRREVAKTV FCLVLVFALCWLPLHLSRILKHTLYDQNDPHRCELLSFLLVLEYIGINMASLNSCINPIA LYLVSKRFKNCFKWCLCCWCQSFEEKQSLEDKQSCLKFKANDHGYDNFRSSNKYSSS
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白標(biāo)簽：
    N-terminal 10xHis-tagged
  • 產(chǎn)品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 儲(chǔ)存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Non-specific receptor for endothelin 1, 2, and 3. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.
  • 基因功能參考文獻(xiàn)：
    1. Hyperinsulinemia caused significant changes in endothelin receptor expression, which suggested that ETR antagonists might be beneficial for treatment of laminitis in horses. PMID: 24669922
    2. both ETA and ETB receptors are involved in the net tonic response to ET-1 in normal laminar veins; a population of ETB receptors may be present on the vascular endothelium and on smooth muscle of laminar veins PMID: 18487099
  • 相關(guān)疾病：
    Defects in EDNRB are a cause of overo lethal white syndrome (OLWS) also known as lethal white foal syndrome (LWFS). It is an inherited syndrome of foals born to American paint horse parents of the overo coat-pattern lineage. Affected foals are totally or almost totally white and die within days from complications due to intestinal aganglionosis.
  • 亞細(xì)胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    G-protein coupled receptor 1 family, Endothelin receptor subfamily, EDNRB sub-subfamily
  • 數(shù)據(jù)庫(kù)鏈接：