Recombinant Human ORM1-like protein 3 (ORMDL3)
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中文名稱:人ORMDL3重組蛋白
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貨號:CSB-CF854016HU
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規(guī)格:
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來源:in vitro E.coli expression system
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其他:
產(chǎn)品詳情
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基因名:ORMDL3
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Uniprot No.:
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別名:ORMDL3; ORM1-like protein 3
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種屬:Homo sapiens (Human)
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蛋白長度:full length protein
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表達(dá)區(qū)域:1-153
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氨基酸序列MNVGTAHSEVNPNTRVMNSRGIWLSYVLAIGLLHIVLLSIPFVSVPVVWTLTNLIHNMGM YIFLHTVKGTPFETPDQGKARLLTHWEQMDYGVQFTASRKFLTITPIVLYFLTSFYTKYD QIHFVLNTVSLMSVLIPKLPQLHGVRIFGINKY
Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request. -
蛋白標(biāo)簽:N-terminal 10xHis-tagged
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產(chǎn)品提供形式:Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand. -
緩沖液:Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
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儲存條件:Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
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保質(zhì)期:The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C. -
貨期:Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
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注意事項(xiàng):Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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Datasheet & COA:Please contact us to get it.
相關(guān)產(chǎn)品
靶點(diǎn)詳情
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功能:Negative regulator of sphingolipid synthesis. May indirectly regulate endoplasmic reticulum-mediated Ca(+2) signaling.
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基因功能參考文獻(xiàn):
- ORMDL3 inhibits the generation of sphingolipids including ceramide and S1P PMID: 27826095
- These associations with ORMDL3 are cell type specific, with the most significant 17q21 genotype effects on ORMDL3 expression and HSPA5 induction evident in B cells. Together, these findings have implications for how the interaction of increased ORMDL3 and rhinovirus may predispose to asthma. PMID: 28192616
- IRF-3 is an important regulator of ORMDL3 induction following RSV infection by binding directly to the promoter of ORMDL3 PMID: 28336364
- MiR-665 induced apoptosis by inhibiting XBP1 and ORMDL3. PMID: 28333149
- These studies suggest that increased levels of ORMDL3 contribute to antiviral defense to rhinovirus infection in mice (hORMDL3(zp3-Cre) mice which have universal increased expression of human ORMDL3) through pathways that may include IFNs (IFN-alpha, IFN-beta, IFN-lambda), OAS, and RNAse L. PMID: 28827284
- this study demonstrated the upregulation of ORMDL3 in patients with systemic lupus erythematosus PMID: 28747345
- ORMDL3 might influence de novo sphingolipid metabolism downstream of serine palmitoyltransferase PMID: 27645259
- modest changes (8-13%) in promoter methylation levels of ZPBP2 and GSDMA may cause substantial changes in RNA levels and allelic expression of ZPBP2 and ORMDL3 is mediated by DNA methylation PMID: 28241063
- Decreased ORMDL3 expression increased levels of free sphingoid bases and sphingoid base phosphates, and also caused increases in cellular levels of ceramides. PMID: 27313060
- ORMDL3 overexpression is associated with asthma. PMID: 27784618
- The TT homozygote and the T allele of rs7216389 in ORMDL3 increased bronchiolitis risk. The rs7216389 polymorphism may be a predictor for identifying infants with predisposition to virus-induced wheezing to persistent asthma. PMID: 26782568
- Two single nucleotide polymorphisms regulating ORMDL3 expression (rs7216389 and rs9303277) significantly associated with atherosclerosis risk and the evidence of increased ORMDL3 expression in AS cases compared to controls. PMID: 26603569
- The SNP (rs7216389) of ORMDL3 does not influence the expression of OPN and TGF-beta1, suggesting that it may not be associated with airway remodeling. PMID: 27097577
- ORMDL3 variants have been shown to be associated with Asthma in children with Rhinovirus infections -induced wheezing illnesses. PMID: 26270739
- The meta-analysis indicates that ORMDL3 rs7216389 may contribute to increasing susceptibility to asthma. (Meta-analysis) PMID: 26125920
- genetic polymorphisms are associated with childhood asthma, and with changes in TH2 cytokines levels PMID: 25930191
- the contribution of ORMDL3 to asthma risk may involve changes in sphingolipid metabolism PMID: 25691431
- results show that Cbl-b suppresses human ORMDL3 expression through STAT6 PMID: 26112603
- Pro-inflammatory gene ORMDL3 SNP rs12603332 may be associated with high LysoPC and apoB levels, which leads to the occurrence of childhood asthma. PMID: 25815492
- Studies indicate that genetic variation of the ORMDL3 rs7216389 polymorphism may be a major independent predisposing factor for asthma in ethnically diverse populations. PMID: 25167772
- The ORMDL3 locus on chromosome 17q21 is a risk factor for childhood-onset asthma in the Northeastern Han Chinese population. PMID: 24649901
- All-trans retinoic acid modulates ORMDL3 expression via transcriptional regulation. PMID: 24204796
- results suggest that rs2872507 is associated with ORMDL3 gene expression and with inhaled corticosteroid treatment response in children with atopic asthma. PMID: 22986918
- Genetic variants of ORMDL3 on chromosome 17q21 are associated with ankylosing spondylitis susceptibility and severity in a Chinese Han population. PMID: 24219690
- signaling pathway cAMP/PKA/CREB plays an important role in regulating ORMDL3 expression PMID: 23577138
- The ORMDL3 gene influences childhood asthma and that the TT genotype of the rs7216389 polymorphism is associated with childhood asthma in the Chinese population. PMID: 23096927
- A polymorphism in ORMDL3 is associated not only with asthma without rhinitis but also with chronic obstructive pulmonary disease. PMID: 23964555
- We have shown that ORMDL3 expression levels modify T-cell calcium signaling and lymphocyte activation. PMID: 23100328
- STAT6 plays important roles in regulating the expression of human ORMDL3 by directly binding to the promoter region. PMID: 23461825
- ORMDL3 genetic variants in the 17q21 asthma susceptibility locus are significantly associated with AR in the Japanese population. PMID: 23157251
- Data show that transfection of ORMDL3 in bronchial epithelial cells induced expression of MMP-9, ADAM-8, CCL-20, IL-8, CXCL-10, CXCL-11, oligoadenylate synthetases (OAS) genes, and selectively activated activating transcription factor 6 (ATF6). PMID: 23011799
- allele-specific transcriptional regulation of genes in the asthma-associated chromosomal region 17q12-q21; rs4795397 influences activity of ZPBP2 promoter in an allele-dependent fashion; methylation of exon 1 of ZPBP2 masks the genetic effect on ZPBP2 promoter; ORMDL3 promoter is unmethylated PMID: 22271045
- Several polymorphisms in ORMDL3, including rs7216389, rs4378650, rs8076131 and rs4795405, have been associated with childhood asthma risk. PMID: 22017802
- This study reveals the presence of a novel ORMDL3 splicing isoform, ORMDL3 V1 in human. PMID: 22015541
- The TTAA haplotype of the ORMDL3 gene is marginally associated with asthma in the adult Czech population, and TCAG haplotype is significantly associated with asthma in males. PMID: 21843571
- Results suggest an association of 17q21 polymorphisms with ORMDL3, GSDMA expression, and IL-17 secretion early in life. These observations may imply a functional role of the 17q21 locus affecting T-cell development during immune maturation. PMID: 21546069
- analysis of whole-genome SNP data in 986 self-reported asthma cases and 1846 controls confirms that variants in ORMDL3 associate with asthma in European and North American populations PMID: 21150878
- Data indicat that Association analysis using risk variants for CD led to the identification of a new risk variant associated with AS, ORMDL3. PMID: 21072187
- ORMDL3 binds and inhibits SERCA resulting in a reduced ER Ca(2+) concentration and increased unfolded-protein response. PMID: 19819884
- results indicate that genetic variants regulating ORMDL3 expression are determinants of susceptibility to childhood asthma PMID: 17611496
- a significant association between susceptibility to childhood atopic asthma and the polymorphism regulating ORMDL3 expression in a Japanese population PMID: 18155279
- results confirm associations between two SNPs within ORMDL3 and asthma in Mexicans and African Americans, and a trend toward association in Puerto Ricans PMID: 18310477
- A common genetic variation at a locus (rs7216389) controlling expression of the ORMDL3 gene increases patient susceptibility to asthma and is associated with poor control of asthma symptoms in children and young adults. PMID: 18395550
- ORMDL3 variants associated with asthma susceptibility in North Americans of European ancestry. PMID: 18760456
- Childhood asthma and atopy are associated with chromosome 17q21 in Chinese, but such association may involve genes other than ORMDL3 in this region. PMID: 19175592
- multiple SNP associations were replicated in both IRAK-3 and ORMDL3, these likely reflect a single disease susceptibility locus in each gene PMID: 19264973
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相關(guān)疾病:Asthma (ASTHMA)
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亞細(xì)胞定位:Endoplasmic reticulum membrane; Multi-pass membrane protein.
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蛋白家族:ORM family
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組織特異性:Widely expressed. Expressed in adult and fetal heart, brain, lung, liver, skeletal muscle and kidney. Expressed in adult pancreas and placenta and in fetal spleen abd thymus.
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