Recombinant Human Phosphatidylethanolamine N-methyltransferase (PEMT)
-
中文名稱:人PEMT重組蛋白
-
貨號:CSB-CF017780HU
-
規(guī)格:
-
來源:in vitro E.coli expression system
-
其他:
產(chǎn)品詳情
-
基因名:PEMT
-
Uniprot No.:
-
別名:PEMT; PEMPT; PNMT; Phosphatidylethanolamine N-methyltransferase; PEAMT; PEMT; PEMT2; Phospholipid methyltransferase; PLMT
-
種屬:Homo sapiens (Human)
-
蛋白長度:Full Length of Mature Protein
-
表達區(qū)域:2-199
-
氨基酸序列TRLLGYVDPLDPSFVAAVITITFNPLYWNVVARWEHKTRKLSRAFGSPYLACYSLSVTIL LLNFLRSHCFTQAMLSQPRMESLDTPAAYSLGLALLGLGVVLVLSSFFALGFAGTFLGDY FGILKEARVTVFPFNILDNPMYWGSTANYLGWAIMHASPTGLLLTVLVALTYIVALLYEE PFTAEIYRQKASGSHKRS
Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request. -
蛋白標簽:N-terminal 10xHis-tagged
-
產(chǎn)品提供形式:Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand. -
緩沖液:Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
-
儲存條件:Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
-
保質期:The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C. -
貨期:Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
-
注意事項:Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
-
Datasheet & COA:Please contact us to get it.
相關產(chǎn)品
靶點詳情
-
功能:Catalyzes the three sequential steps of the methylation pathway of phosphatidylcholine biosynthesis, the SAM-dependent methylation of phosphatidylethanolamine (PE) to phosphatidylmonomethylethanolamine (PMME), PMME to phosphatidyldimethylethanolamine (PDME), and PDME to phosphatidylcholine (PC).
-
基因功能參考文獻:
- Study found three gene variants (CLOCK-rs4864548, PEMT-rs936108, and GHRELIN-rs696217) that exhibited uncorrected gene-by-sleep duration interactions in relation to BMI z-scores in a cohort of New Zealand European children. However, no interactions were identified in percentage body fat differences. Notably, these interactions are evident without detectable effects on sleep duration. PMID: 28899534
- In genotypic combination analysis considering PEMT -744GG/CHDH +432GG/BHMT +742GG as the reference combination, PEMT -744GC/CHDH +432GG/BHMT +742GG genotypic combination was significantly higher in mothers of a down syndrome child compared with that in control mothers with an odds ratio of 2.061 (95% CI: 1.10-3.86, P=0.0342). PMID: 27677362
- Results showed that PEMT mRNA expression in liver tissues of non-alcoholic steatohepatitis (NASH) patients was significantly lower than those with simple steatosis suggesting a distinct clinical entity of lean NASH with insufficiency of PEMT activities. PMID: 26883167
- a significant association between the PEMT rs7946 A-allele and a risk of nonalcoholic fatty liver disease, with the effect being more prominent in East-Asians, but not in non-Asians (Meta-Analysis) PMID: 26636496
- Data show that phosphatidylethanolamineN-methyltransferase (PEMT) rs12325817 polymorphism only marginally changed the association value with academic achievement. PMID: 26728177
- Data suggest that maternal dietary intake during lactation (here, choline intake exceeding dietary recommendations) can alter hepatic PEMT activity and increase choline content of breast milk. PMID: 26025328
- MTHFR rs1801131 C allele and PEMT rs4646356 T allele were associated with a high risk of type 2 diabetes in Han Chinese. PMID: 25074646
- The GG genotype of the PEMT G774C polymorphism, higher levels of serum homocysteine and lower levels of serum betaine are associated with an increased risk of microangiopathy in patients with diabetes. PMID: 23794489
- PEMT is a functional single nucleotide polymorphism (rs7946) in PEMT with sporadic Alzheimer's disease risk in a Han Chinese population. PMID: 21881829
- the PEMT -774G>C and CHDH +432G>T polymorphisms were associated with sperm concentration. This finding suggests a possible influence of these genes on sperm quality PMID: 22387881
- genetic association studies on endometriosis in a population of women in Poland: Data suggest interaction between an SNP in PEMT (rs4244593) and an SNP in MTHFR (Ala222Val; rs1801133) in infertile women with some indication of endometriosis. PMID: 21429654
- nvestigation of factors affecting liver PEMT activity: PEMT activity is lower in liver samples from women who are homozygous for an SNP in PEMT (rs12325817) PMID: 21411618
- allele-specific ablation of estrogen receptor-DNA interaction in the PEMT locus prevents hormone-inducible PEMT expression, conferring risk of choline deficiency in women PMID: 21059658
- Choline requirements for both women are increased by the genetic polymorphism rs12325817 in phosphatidylethanolamine-N-methyltransferase. PMID: 20861172
- Total intake of choline and genotype can influence the concentrations of choline and its metabolites in the breast milk and blood of lactating women and thereby affect the amount of choline available to the developing infant. PMID: 20534746
- The allele frequency of PEMT did not show a significant difference between normal control group and fatty liver patients (P=0.222). PMID: 19262398
- an examination of the membrane topography of this enzyme PMID: 12431977
- PEMT2 mRNA expression was inversely related to tumor proliferation and to histologic grade. PMID: 12931022
- PEMT-mediated Hcy secretion correlated with the methyltransferase activity of the enzyme, independently of subcellular localization PMID: 15927961
- Val175Met variant of PEMT could be a susceptibility candidate to nonalcoholic steatohepatitis (NASH), because it is more frequently observed in NASH patients and non-obese persons with Val175Met variant of PEMT are facilitated to develop NASH PMID: 17391797
- Human PEMT genes have three unique transcription start sites, which are indicative of either multiple promoters and/or alternative splicing. PMID: 17456783
- The present results suggest that the PEMT gene may contribute to the etiology of schizophrenia. PMID: 17720317
- single nucleotide polymorphisms of choline-metabolizing genes, PEMT -774G>C (rs12325817) and CHDH +432G>T (rs12676), were found be related to breast cancer risk PMID: 18230680
- These data suggest that polymorphisms in PEMT genes relevant to choline metabolism modulate parameters of choline status when folate intake is restricted. PMID: 19167960
- in folate-deplete men, several factors with roles in 1-carbon metabolism interact with the MTHFR C677T genotype to affect plasma homocysteine PMID: 19211833
- No association of the rs4646396 SNP in the PEMT locus with schizophrenia in a Chinese case-control sample. PMID: 19647326
顯示更多
收起更多
-
亞細胞定位:[Isoform 1]: Endoplasmic reticulum membrane; Multi-pass membrane protein. Mitochondrion membrane; Multi-pass membrane protein.; [Isoform 2]: Endoplasmic reticulum membrane; Multi-pass membrane protein.
-
蛋白家族:Class VI-like SAM-binding methyltransferase superfamily, PEMT/PEM2 methyltransferase family
-
數(shù)據(jù)庫鏈接:
Most popular with customers
-
Recombinant Rat Intestinal-type alkaline phosphatase 1 (Alpi) (Active)
Express system: Mammalian cell
Species: Rattus norvegicus (Rat)
-
Recombinant Human Claudin-4 (CLDN4)-VLPs (Active)
Express system: Mammalian cell
Species: Homo sapiens (Human)
-
Recombinant Mouse Complement component C1q receptor (Cd93), partial (Active)
Express system: Mammalian cell
Species: Mus musculus (Mouse)
-
Recombinant Human Carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6) (Active)
Express system: Mammalian cell
Species: Homo sapiens (Human)
-
Recombinant Macaca fascicularis lymphocyte antigen 6 family member G6D (LY6G6D) (Active)
Express system: Yeast
Species: Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
-
Recombinant Human Serine/threonine-protein kinase receptor R3 (ACVRL1), partial (Active)
Express system: Baculovirus
Species: Homo sapiens (Human)
-
Recombinant Human Dipeptidase 3(DPEP3), partial (Active)
Express system: Mammalian cell
Species: Homo sapiens (Human)
-
Recombinant Macaca fascicularis Dipeptidase 3(DPEP3) (Active)
Express system: Mammalian cell
Species: Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)