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Recombinant Human Polymeric immunoglobulin receptor (PIGR)

  • 中文名稱：
    人PIGR重組蛋白
  • 貨號(hào)：
    CSB-CF017981HU
  • 規(guī)格：
  • 來源：
    in vitro E.coli expression system
  • 其他：

產(chǎn)品詳情

  • 基因名：
    PIGR
  • Uniprot No.：
  • 別名：
    PIGR; Polymeric immunoglobulin receptor; PIgR; Poly-Ig receptor; Hepatocellular carcinoma-associated protein TB6
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Full Length of Mature Protein
  • 表達(dá)區(qū)域：
    19-764
  • 氨基酸序列
    KSPIFGPEEVNSVEGNSVSITCYYPPTSVNRHTRKYWCRQGARGGCITLISSEGYVSSKYAGRANLTNFPENGTFVVNIAQLSQDDSGRYKCGLGINSRGLSFDVSLEVSQGPGLLNDTKVYTVDLGRTVTINCPFKTENAQKRKSLYKQIGLYPVLVIDSSGYVNPNYTGRIRLDIQGTGQLLFSVVINQLRLSDAGQYLCQAGDDSNSNKKNADLQVLKPEPELVYEDLRGSVTFHCALGPEVANVAKFLCRQSSGENCDVVVNTLGKRAPAFEGRILLNPQDKDGSFSVVITGLRKEDAGRYLCGAHSDGQLQEGSPIQAWQLFVNEESTIPRSPTVVKGVAGGSVAVLCPYNRKESKSIKYWCLWEGAQNGRCPLLVDSEGWVKAQYEGRLSLLEEPGNGTFTVILNQLTSRDAGFYWCLTNGDTLWRTTVEIKIIEGEPNLKVPGNVTAVLGETLKVPCHFPCKFSSYEKYWCKWNNTGCQALPSQDEGPSKAFVNCDENSRLVSLTLNLVTRADEGWYWCGVKQGHFYGETAAVYVAVEERKAAGSRDVSLAKADAAPDEKVLDSGFREIENKAIQDPRLFAEEKAVADTRDQADGSRASVDSGSSEEQGGSSRALVSTLVPLGLVLAVGAVAVGVARARHRKNVDRVSIRSYRTDISMSDFENSREFGANDNMGASSITQETSLGGKEEFVATTESTTETKEPKKAKRSSKEEAEMAYKDFLLQSSTVAAEAQDGPQEA
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白標(biāo)簽：
    N-terminal 10xHis-tagged
  • 產(chǎn)品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 儲(chǔ)存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Mediates selective transcytosis of polymeric IgA and IgM across mucosal epithelial cells. Binds polymeric IgA and IgM at the basolateral surface of epithelial cells. The complex is then transported across the cell to be secreted at the apical surface. During this process, a cleavage occurs that separates the extracellular (known as the secretory component) from the transmembrane segment.; Through its N-linked glycans ensures anchoring of secretory IgA (sIgA) molecules to mucus lining the epithelial surface to neutralize extracellular pathogens. On its own (free form) may act as a non-specific microbial scavenger to prevent pathogen interaction with epithelial cells.
  • 基因功能參考文獻(xiàn)：
    1. We identified two SLN genes (PIGR and TFAP2A) that provided high prognostic accuracy in SLN-positive melanoma patients (AUC = 0.864). These two SLN genes, along with clinicopathological features, can differentiate the high- and low-risk groups in node-positive melanoma patients. PMID: 27663566
    2. pIgR may be involved in pancreatic ductal adenocarcinoma progression and may be linked stromal activity. Further work on its precise role is mandated in in vivo models, to understand its influence on cancer progression. PMID: 28173980
    3. A genome-wide trans-ethnic interaction study links the PIGR-FCAMR locus to coronary atherosclerosis via interactions between genetic variants and residential exposure to traffic pollution. PMID: 28355232
    4. The polymeric immunoglobulin receptor secretory component structure comprises five immunoglobulin-like domains (D1-D5) arranged as a triangle, with an interface between ligand-binding domains D1 and D5. PMID: 26943617
    5. Reduced expression of the polymeric immunoglobulin receptor in pancreatic and periampullary adenocarcinoma signifies tumour progression and poor prognosis. PMID: 25397670
    6. Crohn disease patients were characterized as having decreased median expression of PIGR, in non-inflamed colonic mucosa. By contrast, Ulcerative colitis patients exhibited decreased expression of PIGR in colon mucosa. PMID: 25956706
    7. Report PIGR expression in human fallopian tubes, primary epithelial ovarian tumours and metastases. PMID: 24568264
    8. the polymeric immunoglobulin receptor (pIgR) is highly expressed by renal cyst-lining cells. pIgR expression is, in part, driven by aberrant STAT6 pathway activation. PMID: 25922073
    9. Positive expression of pIgR was statistically significantly associated with poor prognosis of patients with colon carcinoma hepatic metastasis. PMID: 26176052
    10. In conclusion these data suggest that Streptococcus pneumoniae PspC-promoted uptake via the polymeric immunoglobulin receptor of epithelial cells is mediated by both clathrin and caveolin dependent pathway. PMID: 25455218
    11. Polymeric immunoglobulin receptor expression is correlated with poor prognosis in patients with osteosarcoma. PMID: 24699841
    12. High PIGR expression independently predicts a decreased risk of recurrence and an improved survival in patients with adenocarcinoma of the upper gastrointestinal tract PMID: 24694107
    13. pIgR down-regulation in chronic obstructive pulmonary disease correlates with severity. Bronchial epithelium in vitro retains aberrant imprinting for pIgR expression. pIgR down-regulation is linked to TGF-beta-driven reprogramming of bronchial epithelium. PMID: 25078120
    14. Results indicated that the polymeric immunoglobulin receptor (pIgR) can be divided into several functionally distinct regions. PMID: 23809084
    15. Polymeric immunoglobulin receptor (PIGR)expression was lost in most lung cancers and pre-invasive bronchial lesions, suggesting that PIGR downregulation is an early event in lung tumourigenesis. PIGR overexpression inhibited cell proliferation. PMID: 21965228
    16. The comparison of nonsmokers, smokers, and smokers with moderate COPD revealed 15 changed proteins with the majority, including polymeric immunoglobulin receptor (PIGR), being elevated in smokers and subjects with COPD. PMID: 22053820
    17. Both native and phage-bound variable domain of camelid derived heavy chain only antibodies, were only able to get across polarized MDCK cells that express the human pIgR gene in a basolateral to apical fashion. PMID: 22022593
    18. Results identify pIgR as a potential link between hepatitis B virus-derived hepatitis and HCC metastasis and provide evidence in support of pIgR as a prognostic biomarker for HCC and a potential therapeutic target. PMID: 22025622
    19. Streptococcus pneumoniae infection of host epithelial cells via polymeric immunoglobulin receptor transiently induces calcium release from intracellular stores. PMID: 21454571
    20. Data illustrate the importance of a coordinated signaling between Src PTKs, ERK1/2, and JNK during pIgR-mediated uptake of pneumococci by host epithelial cells. PMID: 20829350
    21. characterization of the human pIgR promoter and the essential role that eight different nuclear complexes have in controlling basal expression of this gene in Caco-2 cells PMID: 12121890
    22. cooperative binding of multiple transcription factors regulates basal activity of the human PIGR promoter PMID: 12165516
    23. facilitates invasion of epithelial cells by Streptococcus pneumoniae in a strain-specific and cell type-specific manner PMID: 12183558
    24. The carboxyl-terminal domains of IgA and IgM direct isotype-specific polymerization and interaction with this receptor PMID: 12213814
    25. This protein is cleaved by neutrophil serine proteinases but its epithelial production is increased by neutrophils through NF-kappa B- and p38 mitogen-activated protein kinase-dependent mechanisms. PMID: 12654638
    26. It seems that a gene associated with susceptibility to immunoglobulin A nephropathy lies within or close to the PIGR gene locus on chromosome 1q in the Japanese population. PMID: 12740691
    27. there is a conformational CbpA-binding motif in the D3/D4 region of human polymeric immunoglobulin receptor, which is functionally separated from the IgA-binding site PMID: 13679368
    28. transcription factors upstream stimulatory factor (USF) and c-Myc may exert opposing effects on PIGR promoter activity PMID: 14644095
    29. Ectodomains 3 and 4 of human polymeric Immunoglobulin receptor have a role in mediating adherence and internalization of Streptococcus pneumoniae into epithelial cells PMID: 14660617
    30. TNF-induced up-regulation of the human pIgR critically depends on an NF-kappa B site and flanking sequences within a 204-bp region of the first intron in the pIgR gene, a region largely overlapping with a recently characterized IL-4-responsive enhancer. PMID: 15265917
    31. USF1 and USF2 mRNA levels were reduced in non-small cell lung carcinoma; AP2-alpha levels were elevated; regression analysis demonstrated that reduced USF2 mRNA & increased AP2-alpha mRNA levels were predictive of downregulated PIGR mRNA expression PMID: 15864740
    32. TLR3 and TLR4 signal primarily through NF-kappaB to enhance transcription of pIgR mRNA. PMID: 15972671
    33. This review expands our view of the immunobiology of pIgR, a key component of the mucosal immune system that bridges innate and adaptive immune defense. PMID: 16048543
    34. interaction of dimeric IgA (dIgA) (the predominant form of IgA polymer) with the pIgR PMID: 16272325
    35. Secretory component (SC) is derived from the polymeric immunoglobulin receptor (pIgR). The purified free form of SC binds IgM with a physiological equilibrium dissociation constant of 4.6x10(-8) M and shares structural similarity to native SC. PMID: 16288892
    36. This work represents the first analysis of the three-dimensional structure of full-length free secretory component (SC) and paves the way to a better understanding of the association between SC and its potential ligands. PMID: 17428798
    37. In cultured Caco-2 cells, tumor necrosis factor-alpha (TNF-alpha) dose-dependently increased polymeric immunoglobulin receptor (pIg) mRNA. PMID: 17460948
    38. Fcalpha/muR had different tissue distribution patterns to pIgR in the intestine. PMID: 19338768
    39. A novel NF-kappa B/Rel site in intron 1 cooperates with proximal promoter elements to mediate TNF-alpha-induced transcription of the human polymeric Ig receptor PMID: 11714807
    40. IL-4 responsiveness mediated by an enhancer located in intron 1; both direct and indirect involvement of STAT6 PMID: 11034397

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  • 亞細(xì)胞定位：
    [Polymeric immunoglobulin receptor]: Cell membrane; Single-pass type I membrane protein.; [Secretory component]: Secreted.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 8968

    OMIM: 173880

    KEGG: hsa:5284

    STRING: 9606.ENSP00000348888

    UniGene: Hs.497589