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Recombinant Human Probable G-protein coupled receptor 61 (GPR61)

  • 中文名稱：
    人GPR61重組蛋白
  • 貨號：
    CSB-CF866330HU
  • 規(guī)格：
  • 來源：
    in vitro E.coli expression system
  • 其他：

產(chǎn)品詳情

  • 基因名：
  • Uniprot No.：
  • 別名：
    GPR61; BALGR; GPCR3; G-protein coupled receptor 61; Biogenic amine receptor-like G-protein coupled receptor
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    full length protein
  • 表達(dá)區(qū)域：
    1-451
  • 氨基酸序列
    MESSPIPQSSGNSSTLGRVPQTPGPSTASGVPEVGLRDVASESVALFFMLLLDLTAVAGN AAVMAVIAKTPALRKFVFVFHLCLVDLLAALTLMPLAMLSSSALFDHALFGEVACRLYLF LSVCFVSLAILSVSAINVERYYYVVHPMRYEVRMTLGLVASVLVGVWVKALAMASVPVLG RVSWEEGAPSVPPGCSLQWSHSAYCQLFVVVFAVLYFLLPLLLILVVYCSMFRVARVAAM QHGPLPTWMETPRQRSESLSSRSTMVTSSGAPQTTPHRTFGGGKAAVVLLAVGGQFLLCW LPYFSFHLYVALSAQPISTGQVESVVTWIGYFCFTSNPFFYGCLNRQIRGELSKQFVCFF KPAPEEELRLPSREGSIEENFLQFLQGTGCPSESWVSRPLPSPKQEPPAVDFRIPGQIAE ETSEFLEQQLTSDIIMSDSYLRPAASPRLES
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白標(biāo)簽：
    N-terminal 10xHis-tagged
  • 產(chǎn)品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    Orphan G-protein coupled receptor. Constitutively activates the G(s)-alpha/cAMP signaling pathway. Shows a reciprocal regulatory interaction with the melatonin receptor MTNR1B most likely through receptor heteromerization. May be involved in the regulation of food intake and body weight.
  • 基因功能參考文獻：
    1. maps to chromosome 1, is widely expressed, with expression highest in the brain areas associated with cognition, learning, and memory. PMID: 11690637
    2. Modeling rationalizes the effects of transmembrane proline mutants previously reported for another family of GPCR. PMID: 15615699
    3. We conclude that the N-terminal domain of GPR61 is required for maintaining its constitutive activity and functions as a tethered intramolecular ligand. PMID: 19025769
  • 亞細(xì)胞定位：
    Cell membrane; Multi-pass membrane protein. Endosome membrane; Multi-pass membrane protein.
  • 蛋白家族：
    G-protein coupled receptor 1 family
  • 組織特異性：
    Expressed in brain; detected in frontal and temporal lobes, occipital pole, amygdala and hippocampus. Also expressed in testis and T cells, B cells, and monocyte. Low expression in many other tissues. Widely expressed in the hippocampus (at protein level)
  • 數(shù)據(jù)庫鏈接：

    HGNC: 13300

    OMIM: 606916

    KEGG: hsa:83873

    STRING: 9606.ENSP00000385422

    UniGene: Hs.709782