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  4. Recombinant Human Progestin and adipoQ receptor family member 3 (PAQR3)

Recombinant Human Progestin and adipoQ receptor family member 3 (PAQR3)

  • 中文名稱：
    人PAQR3重組蛋白
  • 貨號：
    CSB-CF757752HU
  • 規(guī)格：
  • 來源：
    in vitro E.coli expression system
  • 其他：

產(chǎn)品詳情

  • 基因名：
    PAQR3
  • Uniprot No.：
  • 別名：
    PAQR3; Progestin and adipoQ receptor family member 3; Progestin and adipoQ receptor family member III; Raf kinase trapping to Golgi; RKTG
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    full length protein
  • 表達(dá)區(qū)域：
    1-311
  • 氨基酸序列
    MHQKLLKSAHYIELGSYQYWPVLVPRGIRLYTYEQIPGSLKDNPYITDGYRAYLPSRLCI KSLFILSNETVNIWSHLLGFFLFFTLGIYDMTSVLPSASASREDFVICSICLFCFQVCML CSVGYHLFSCHRSEKTCRRWMALDYAGISIGILGCYVSGVFYAFYCNNYWRQVYLITVLA MILAVFFAQIHPNYLTQQWQRLRSIIFCSVSGYGVIPTLHWVWLNGGIGAPIVQDFAPRV IVMYMIALLAFLFYISKVPERYFPGQLNYLGSSHQIWHILAVVMLYWWHQSTVYVMQYRH SKPCPDYVSHL
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白標(biāo)簽：
    N-terminal 10xHis-tagged
  • 產(chǎn)品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    Functions as a spatial regulator of RAF1 kinase by sequestrating it to the Golgi.
  • 基因功能參考文獻(xiàn)：
    1. Ubiquitination modification through the coordinated action of PAQR3 with HUWE1 plays a crucial role in regulating the activity of hepatic PPARalpha in response to starvation. PMID: 29331071
    2. Silencing of PAQR3 suppresses extracellular matrix accumulation in high glucose-stimulated human glomerular mesangial cells via PI3K/AKT signaling pathway PMID: 29787774
    3. that PAQR3 can be a promising methylation marker candidate for the detection and monitoring of prostate cancer PMID: 29122400
    4. PAQR3 is epigenetically silenced in esophageal squamous cell carcinoma (ESCC) and restoration of PAQR3 suppresses the aggressive phenotype of ESCC cells PMID: 28802234
    5. Low expression of PAQR3 is associated with gastric cancer metastasis. PMID: 28560431
    6. Data suggest that expression of PAQR3 is down-regulated in glioma tissues and cell lines; PAQR3 overexpression suppresses cell migration of glioma cells, suppresses invasivness of glioma in xenograft experiments, and prevents epithelial-mesenchymal transition. PMID: 28528182
    7. our study pinpoints that PAQR3 functions as an adaptor protein to promote Nrf2-Keap1 complex formation, thereby modulating the Nrf2-Keap2 pathway and playing an important role in controlling antioxidant response of the cell PMID: 27212020
    8. This finding reveals a new mode of regulation of mTORC1 signaling and autophagy by PAQR3 in response to alterations of amino acids. PMID: 28214587
    9. we demonstrated that overexpression of PAQR3 suppresses cell proliferation, migration, and invasion in esophageal cancer in vitro and in vivo. PMID: 28548040
    10. The expression of PAQR3 protein significantly decreased in lung cancer. PMID: 28442015
    11. our results suggested that the aberrant methylation of PAQR3 underlies its downregulation in breast cancer and our data indicated that epigenetic silencing of PAQR3 gene expression by promoter hypermethylation may play an important role in breast cancer PMID: 27461225
    12. PAQR3 plays a tumor suppressive role in laryngeal squamous cell carcinoma PMID: 26232324
    13. A novel role for the newly characterized, Golgi-localized PAQR3 in regulating heterotrimeric G-proteins at the non-canonical subcellular location of the Golgi. PMID: 26327583
    14. findings not only pinpoint that Twist1 mediates the modulatory function of PAQR3 on EMT and metastasis but also suggest that targeting Twist1 is a promising strategy to control metastasis of tumors with downregulation of PAQR3 PMID: 26905590
    15. PAQR3 regulates cholesterol homeostasis by anchoring Scap/SREBP to the Golgi and disruption of such function reduces cholesterol biosynthesis. PMID: 26311497
    16. Our data indicate that PAQR3 functions as a tumor suppressor in the development of human breast cancers. PMID: 25900239
    17. DDB2 is involved in ubiquitination and degradation of PAQR3 in gastric cancer cells. PMID: 26205499
    18. PAQR3 is markedly down-regulated in human gastric cancers. PAQR3 expression level is closely associated with the progression and metastasis of gastric cancers PMID: 24799462
    19. PAQR3 might act as a tumor suppressor in osteosarcoma. PMID: 25510670
    20. PAQR3 may play an important role in the progression of hepatocellular carcinoma and serve as a potential candidate for the targeted therapy of hepatocellular carcinoma PMID: 25310770
    21. PAQR3 (progestin and adipoQ receptors member 3), a tumour suppressor specifically localized in the Golgi apparatus, negatively regulates H3K4 trimethylation (H3K4me3). PMID: 25706881
    22. MicroRNA-137 upregulation increases bladder cancer cell proliferation and invasion by targeting PAQR3 PMID: 25330156
    23. Loss of PAQR3 is associated with tumorigenesis of colorectal cancers. PMID: 22828136
    24. RKTG can modulate GPCR signaling through sequestering G betagamma to the Golgi apparatus and thereby attenuating the functions of G betagamma. PMID: 19884349
    25. reveal a paradigm of spatial regulation of Raf kinase by RKTG via sequestrating Raf-1 to the Golgi apparatus and thereby inhibiting the ERK signaling pathway. PMID: 17724343
    26. RKTG may play a suppressive role in human melanoma that harbors an oncogenic B-Raf mutation via its antagonistic action on B-Raf. PMID: 18515281
    27. Analysis in detail of the topology and functional domains of RKTG (Raf kinase trapping to Golgi). PMID: 18547165
    28. Data show that adiponectin functions as an agonist of PAQR3. PMID: 19519172

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  • 亞細(xì)胞定位：
    Golgi apparatus membrane; Multi-pass membrane protein.
  • 蛋白家族：
    ADIPOR family
  • 組織特異性：
    Widely expressed in a range of tissues.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 30130

    OMIM: 614577

    KEGG: hsa:152559

    STRING: 9606.ENSP00000421981

    UniGene: Hs.657312