PAQR9; Membrane progestin receptor epsilon; mPR epsilon; Membrane progesterone P4 receptor epsilon; Membrane progesterone receptor epsilon; Progesterone and adipoQ receptor family member 9; Progestin and adipoQ receptor family member 9; Progestin and adipoQ receptor family member IX
種屬:
Homo sapiens (Human)
蛋白長度:
full length protein
表達(dá)區(qū)域:
1-377
氨基酸序列
MPRRLQPRGAGTKGPPAPAPAASGAARNSHSAASRDPPASAKPLLRWDEVPDDFVECFIL
SGYRRLPCTAQECLASVLKPTNETLNFWTHFIPLLLFLSKFCRLFFLSGGDVPFHHPWLL
PLWCYASGVLLTFAMSCTAHVFSCLSLRLRAAFFYLDYASISYYGFGSTVAYYYYLLPGL
SLLDARVMTPYLQQRLGWHVDCTRLIAAYRALVLPVAFVLAVACTVACCKSRTDWCTYPF
ALRTFVFVMPLSMACPIMLESWLFDLRGENPTLFVHFYRRYFWLVVAAFFNVSKIPERIQ
PGLFDIIGHSHQLFHIFTFLSIYDQVYYVEEGLRQFLQAPPAAPTFSGTVGYMLLLVVCL
GLVIRKFLNSSEFCSKK Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
蛋白標(biāo)簽:
N-terminal 10xHis-tagged
產(chǎn)品提供形式:
Liquid or Lyophilized powder Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
緩沖液:
Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
儲存條件:
Store at -20°C/-80°C upon receipt, aliquoting is necessary for
mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期:
The shelf life is related to many factors, storage state,
buffer ingredients, storage temperature and the stability of the protein
itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The
shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期:
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our
proteins are default shipped with normal blue ice packs, if you
request to ship with dry ice, please communicate with us in advance
and extra fees will be charged.
注意事項:
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Plasma membrane progesterone (P4) receptor coupled to G proteins. Seems to act through a G(s) mediated pathway. May be involved in regulating rapid P4 signaling in the nervous system. Also binds dehydroepiandrosterone (DHEA), pregnanolone, pregnenolone and allopregnanolone.
基因功能參考文獻(xiàn):
The results suggest that PAQR6 and PAQR9 (mPRdelta and mPRepsilon) function as mPRs coupled to G proteins and are potential intermediaries of nonclassical antiapoptotic actions of neurosteroids in the central nervous system. PMID: 23161870
PAQR9 is a previously uncharacterized PAQR which is also capable of responding to progesterone. PMID: 18603275
亞細(xì)胞定位:
Cell membrane; Multi-pass membrane protein.
蛋白家族:
ADIPOR family
組織特異性:
Expression levels vary widely in a range of tissues. Expressed in the brain, at high level in the pituitary gland and also in hypothalamus, limbic system, caudate nucleus accumens, pons and olfactory bulb.