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Recombinant Human Vang-like protein 1 (VANGL1)

  • 中文名稱：
    人VANGL1重組蛋白
  • 貨號(hào)：
    CSB-CF848385HU
  • 規(guī)格：
  • 來(lái)源：
    in vitro E.coli expression system
  • 其他：

產(chǎn)品詳情

  • 基因名：
  • Uniprot No.：
  • 別名：
    VANGL1; STB2; Vang-like protein 1; Loop-tail protein 2 homolog; LPP2; Strabismus 2; Van Gogh-like protein 1
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長(zhǎng)度：
    full length protein
  • 表達(dá)區(qū)域：
    1-524
  • 氨基酸序列
    MDTESTYSGYSYYSSHSKKSHRQGERTRERHKSPRNKDGRGSEKSVTIQPPTGEPLLGND STRTEEVQDDNWGETTTAITGTSEHSISQEDIARISKDMEDSVGLDCKRYLGLTVASFLG LLVFLTPIAFILLPPILWRDELEPCGTICEGLFISMAFKLLILLIGTWALFFRKRRADMP RVFVFRALLLVLIFLFVVSYWLFYGVRILDSRDRNYQGIVQYAVSLVDALLFIHYLAIVL LELRQLQPMFTLQVVRSTDGESRFYSLGHLSIQRAALVVLENYYKDFTIYNPNLLTASKF RAAKHMAGLKVYNVDGPSNNATGQSRAMIAAAARRRDSSHNELYYEEAEHERRVKKRKAR LVVAVEEAFIHIQRLQAEEQQKAPGEVMDPREAAQAIFPSMARALQKYLRITRQQNYHSM ESILQHLAFCITNGMTPKAFLERYLSAGPTLQYDKDRWLSTQWRLVSDEAVTNGLRDGIV FVLKCLDFSLVVNVKKIPFIILSEEFIDPKSHKFVLRLQSETSV
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白標(biāo)簽：
    N-terminal 10xHis-tagged
  • 產(chǎn)品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 儲(chǔ)存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 基因功能參考文獻(xiàn)：
    1. High KITENIN expression is associated with cholangiocarcinoma. PMID: 29366806
    2. VANGL1 gene is not associated with Adolescent Idiopathic Scoliosis in the Chinese population PMID: 29189642
    3. two rare missense mutations in VANGL1, encoding a receptor involved in WNT/PCP signaling, may be associated with Adolescent Idiopathic Scoliosis PMID: 27755493
    4. Study provides evidence that KITENIN functions in the maintenance of a higher expression level of ErbB4 in advanced colorectal cancer tissues, independent of ubiquitin-mediated degradation via Nrdp1. PMID: 27648936
    5. We first propose the use of a DNA biosensor to detect the missense single nucleotide polymorphism (rs4839469 c.346G>A p.Ala116Thr) of the vangl1 gene PMID: 26914375
    6. a novel and ultrasensitive sandwich-type immunosensor was fabricated to detect Vangl in human serum using C60-templated AuPt as labels and rGO-TEPA-PTC-NH2 as the platform. PMID: 26735870
    7. Results found that KITENIN is associated with tumor progression by enhancing angiogenesis in colorectal cancer. PMID: 26496979
    8. Authors silenced VANGL1 gene expression in the HepG2 HCC cell line by stable transfection with a vector containing siRNA template for VANGL1 and investigated the change in cell invasion and motility. PMID: 25874746
    9. High levels of KITENIN increased glioma invasiveness and progression, and are associated with the up-regulation of EMT and stemness markers. PMID: 25605251
    10. The rs4839469 allele of VANGL1 was obviously associated with neural tube defects (NTDs). And genotype GC increased the risk of NTDs, changes in the three-dimensional protein structure may have impacted its biological functions. PMID: 24407469
    11. VANGL1 mutations are associated with neural tube defects. PMID: 25208524
    12. Elevated KITENIN expression is associated with drug resistance in colorectal cancer. PMID: 24893630
    13. Findings identify that KITENIN-targeting miR-124, miR-27a, and miR-30b function as endogenous inhibitors of colorectal cancer cell motility and demonstrate that miR-124 plays a suppressor role in colorectal tumorigenesis. PMID: 24909917
    14. The results show that the Vangl1 amino terminus lacks PM targeting determinants, and these are restricted to the carboxy terminus, including the predicted PDZBM motif at the C-terminus PMID: 24452931
    15. KITENIN is associated with tumor invasiveness and metastasis in human oral cavity squamous cell carcinoma. PMID: 22840317
    16. NOS1AP colocalizes with both SCRIB and VANGL1 along cellular protrusions in metastatic breast cancer cells, but does not colocalize with either SCRIB or VANGL1 at cell junctions in normal breast cells PMID: 22179838
    17. KITENIN is associated with human colorectal cancer progression including invasion and metastasis. PMID: 21418393
    18. a compact membrane-associated portion with very short predicted extra- and intracellular loops, while the protein harbors a large intracellular domain PMID: 21291170
    19. This study demonstrates a high degree of functional conservation of VANGL genes across evolution and provides a model system for studying potential variants identified in human neural tube defects. PMID: 20043994
    20. KITENIN plays an important role in human gastric cancer progression by AP-1 activation. PMID: 20944126
    21. Molecular cloning and characterization of Strabismus 2 PMID: 11956595
    22. VANGL protein may serve as an effector mediating the intestinal trefoil factor (ITF) healing response of the intestinal mucosa. PMID: 16410243
    23. In a protein-protein interaction assay V239I abolished interaction of VANGL1 protein with its binding partners, disheveled-1, -2, and -3. These findings implicate VANGL1 as a risk factor in human neural-tube defects. PMID: 17409324
    24. VANGL1 increases invasion and migration of mouse squamous cancer cells and promotes pulmonary metastasis in a mouse squamous tumor model. PMID: 19166844
    25. role of VANGL1 as a risk factor in the development of spinal neural tube defects PMID: 19319979

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  • 相關(guān)疾病：
    Neural tube defects (NTD); Sacral defect with anterior meningocele (SDAM)
  • 亞細(xì)胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Vang family
  • 組織特異性：
    According to PubMed:11956595, ubiquitously expressed. According to PubMed:12011995, expressed specifically in testis and ovary.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 15512

    OMIM: 182940

    KEGG: hsa:81839

    STRING: 9606.ENSP00000310800

    UniGene: Hs.515130