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  4. Recombinant Human herpesvirus 1 Virion egress protein UL34 (UL34)

Recombinant Human herpesvirus 1 Virion egress protein UL34 (UL34)

  • 中文名稱：
    Recombinant Human herpesvirus 1 Virion egress protein UL34(UL34)
  • 貨號：
    CSB-CF319872HWY
  • 規(guī)格：
  • 來源：
    in vitro E.coli expression system
  • 其他：

產品詳情

  • 基因名：
    NEC2
  • Uniprot No.：
  • 別名：
    NEC2; UL34; Nuclear egress protein 2
  • 種屬：
    Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
  • 蛋白長度：
    full length protein
  • 表達區(qū)域：
    1-275
  • 氨基酸序列
    MAGLGKPYTGHPGDAFEGLVQRIRLIVPSTLRGGDGEAGPYSPSSLPSRCAFQFHGHDGS DESFPIEYVLRLMNDWAEVPCNPYLRIQNTGVSVLFQGFFHRPHNAPGGAITPERTNVIL GSTETTGLSLGDLDTIKGRLGLDARPMMASMWISCFVRMPRVQLAFRFMGPEDAGRTRRI LCRAAEQAITRRRRTRRSREAYGAEAGLGVAGTGFRARGDGFGPLPLLTQGPSRPWHQAL RGLKHLRIGPPALVLAAGLVLGAAIWWVVGAGARL
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白標簽：
    N-terminal 10xHis-tagged
  • 產品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Plays an essential role in virion nuclear egress, the first step of virion release from infected cell. Within the host nucleus, NEC1 interacts with the newly formed capsid through the vertexes and directs it to the inner nuclear membrane by associating with NEC2. Induces the budding of the capsid at the inner nuclear membrane as well as its envelopment into the perinuclear space. There, the NEC1/NEC2 complex promotes the fusion of the enveloped capsid with the outer nuclear membrane and the subsequent release of the viral capsid into the cytoplasm where it will reach the secondary budding sites in the host Golgi or trans-Golgi network.
  • 基因功能參考文獻：
    1. Identified HSV-1 UL34 as a viral factor that mediated ER remodeling; demonstrated that UL34 was required for efficient targeting of these regulators to the nuclear membrane PMID: 28356536
    2. Report the properties of a point mutant of pUL34 (Q163A) that fails to induce gross changes in nuclear architecture or redistribution of lamin A/C. The UL34(Q163A) mutant shows a roughly 100-fold defect in single-step growth, and it forms small plaques. This mutant has a defect in nuclear egress, and furthermore, it fails to disrupt nuclear shape or cause observable displacement of lamin A/C. PMID: 27654296
    3. Membrane insertion of HSV-1 pUL34 occurs post-translationally. A minimal length of 15 residues is sufficient for stable membrane anchoring. PMID: 21832006
    4. The authors show that a mutation in the inner nuclear membrane-targeting domain of pUL34 fails to support production of infectious virus or plaque formation. PMID: 21900173
    5. targeted to nuclear rim of rabbit skin cells infected with UL31 deletion HSV-1 virus PMID: 15476875
    6. The results suggest a model in which pUS3 and PKCdelta that has been recruited by pUL34 hyperphosphorylate emerin, leading to disruption of its connections with lamin proteins and contributing to the disruption of the nuclear lamina. PMID: 17652388
    7. lamin A/C, lamin B1, and viral US3 kinase have roles in viral infectivity, virion egress, and the targeting of herpes simplex virus U(L)34-encoded protein to the inner nuclear membrane PMID: 18524819
    8. Enrichment of gM in the inner nuclear membrane at the expense of that in the outer nuclear membrane was greatly dependent on UL34. PMID: 19279119

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  • 亞細胞定位：
    Host nucleus inner membrane; Single-pass membrane protein.
  • 蛋白家族：
    Herpesviridae NEC2 protein family
  • 數據庫鏈接：

    KEGG: vg:2703355