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Recombinant Mouse C2 domain-containing protein 2-like (C2cd2l)

  • 中文名稱：
    Recombinant Mouse C2 domain-containing protein 2-like(C2cd2l)
  • 貨號：
    CSB-CF767345MO
  • 規(guī)格：
  • 來源：
    in vitro E.coli expression system
  • 其他：

產(chǎn)品詳情

  • 基因名：
    C2cd2l
  • Uniprot No.：
  • 別名：
    C2cd2l; Tmem24; Phospholipid transfer protein C2CD2L; C2 domain-containing protein 2-like; Transmembrane protein 24
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    full length protein
  • 表達(dá)區(qū)域：
    1-706
  • 氨基酸序列
    MDPDWGQRDVGWAALLVLFAASLITVLGWMLQYARGLWLSRADGGRDSRPASAAEPGGSL RELGVWRSLLRLRATRTSTPEEAGVRGLLASLFAFKSFRENWQRAWVRALNEQACRDGSS IQIAFEEIPQLPPRASISHVTCVDQSERTMVLHCQLSAEEVRFPISVTQQSPAAVSMETY HVTLTLPPTQLEVSLEEIPDEGLLVSWAFTDRPELSLKVLPKLQTRERDEEQPELSTVEE LIKDAIVSTQPAMMVNLRACSAPGGLVPSEKPPTMSQAQPSIPRPTRLFLRQLRASHLGS ELGGTEELCCAAELDNPMQQKWTKPMRAGPEVEWTEDLALDLGPQSRELTLKVLRSSSCG DAELLGQATLPVGSPSRPMSRRQVCPLTPGPGKSLSPAATVTAELHYEQGSPRNLGTPTS STPRPSITPTKKIELDRTIMPDGTVVTTVTTVQSRPRVDGKLDSPSRSPSKVEVTEKMTT VLSESSGPSNASHSSSRESHLSNGLDPVAETAIRQLTEPSGRAAKKTPTKRSTLIISGVS KVPIAQDELVLSLGYAASLEASMQDDAGTSGGPSSPPSDPSATSPGPVDALSSPTSVQEA DETTRSDISERPSVDDVESETGSTGALETRSLKDHKVSFLRSGTKLIFRRRPRQKEAGLS QSHDDLSNTTATPSVRKKAGSFSRRLIKRFSFKSKPKANGNPSPQL
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白標(biāo)簽：
    N-terminal 10xHis-tagged
  • 產(chǎn)品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    Lipid-binding protein that transports phosphatidylinositol, the precursor of phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), from its site of synthesis in the endoplasmic reticulum to the cell membrane. It thereby maintains the pool of cell membrane phosphoinositides, which are degraded during phospholipase C (PLC) signaling. Plays a key role in the coordination of Ca(2+) and phosphoinositide signaling: localizes to sites of contact between the endoplasmic reticulum and the cell membrane, where it tethers the two bilayers. In response to elevation of cytosolic Ca(2+), it is phosphorylated at its C-terminus and dissociates from the cell membrane, abolishing phosphatidylinositol transport to the cell membrane. Positively regulates insulin secretion in response to glucose. Phosphatidylinositol transfer to the cell membrane allows replenishment of PI(4,5)P2 pools and calcium channel opening, priming a new population of insulin granules.
  • 基因功能參考文獻(xiàn)：
    1. Protein expression level differences of C2CD2L, DIRAS2, and PYCR2 in prefrontal neocortex of male M. fascicularis cases discriminates between those with heavy or light voluntary alcohol consumption. Results for C2CD2L were corroborated in chronic intermittent ethanol treated BXD strains of mice, in which the D allele (DBA/2) is associated with lower alcohol consumption than the B allele (C57BL/6J). PMID: 28270566
    2. The identification of TMEM24 in the context of a comprehensive set of sequential insulin-binding partners provides a molecular description of the insulin secretory pathway in beta cells. PMID: 24012759
  • 亞細(xì)胞定位：
    Endoplasmic reticulum membrane; Single-pass membrane protein. Cell membrane; Peripheral membrane protein.
  • 數(shù)據(jù)庫鏈接：

    KEGG: mmu:71764

    UniGene: Mm.491174