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Recombinant Mouse Calcitonin receptor (Calcr)

  • 中文名稱：
    Recombinant Mouse Calcitonin receptor(Calcr)
  • 貨號：
    CSB-CF004439MO
  • 規(guī)格：
  • 來源：
    in vitro E.coli expression system
  • 其他：

產品詳情

  • 基因名：
  • Uniprot No.：
  • 別名：
    Calcr; Calcitonin receptor; CT-R
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Full Length of Mature Protein
  • 表達區(qū)域：
    25-515
  • 氨基酸序列
    APTNLTDSGLDQEPFLYLVGRKKLLDAQYKCYDRIHQLPSYEGEGLYCNRTWDGWMCWDD TPAGATAYQHCPDYFPDFDTAEKVSKYCDENGEWFRHPDSNRTWSNYTLCNAFTSEKLQN AYVLYYLALVGHSLSIAALVASMLIFWIFKNLSCQRVTLHKHMFLTYILNSIIIIIHLVE VVPNGDLVRRDPMHIFHHNTHMWTMQWELSPPLPLCAHEGKMDPHASEVISCKVLHFLHQ YMMSCNYFWMLCEGIYLHTLIVMAVFTDEQRLRWYYLLGWGFPIVPTIIHAITRALYYND NCWLSAETHLLYIIHGPVMVALVVNFFFLLNIVRVLVTKMRQTHEAESYMYLKAVKATMV LVPLLGIQFVVFPWRPSNKVLGKIYDYLMHSLIHFQGFFVATIYCFCNHEVQVTLKRQWT QFKIQWSQRWGRRRPTNRVVSAPRAVAFAEPDGLPIYICHQEPRNPPISNNEGEESTEMI PMNVIQQDASA
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白標簽：
    N-terminal 10xHis-tagged
  • 產品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    This is a receptor for calcitonin. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. The calcitonin receptor is thought to couple to the heterotrimeric guanosine triphosphate-binding protein that is sensitive to cholera toxin.
  • 基因功能參考文獻：
    1. Endosomal signaling of the CLR mediates pain transmission. PMID: 29087309
    2. calcitonin receptor is expressed in the suprachiasmatic nucleus and mediates body temperature fluctuations during the active phase in mice. PMID: 29440246
    3. Calcr knockout resulted in abnormal quiescent state of muscle stem cells, reduction of their pool apoptosis and relocation from the MSC niche. PMID: 26440893
    4. data suggest that Clr-b modulation is a conserved innate host cell response to virus infection that is subverted by multiple CMV immune evasion strategies. PMID: 26044139
    5. upregulated in synovial tissue of osteoarthritic mice by macrophage-derived IL-1 beta PMID: 26400621
    6. protects the maternal skeleton during lactation by a direct action on osteocytes to inhibit osteolysis PMID: 26135836
    7. Together, these data indicate that signaling through RAMP1 and CLR plays a role in mediating asthma pathology PMID: 25010197
    8. The relevance of the OPG/RANK/RANKL system in the particle-induced osteolysis process, was investigated. PMID: 25486133
    9. Nkrp1-Clr gene cluster appears to evolve more slowly relative to the related Ly49 cluster, and likely regulates innate immunosurveillance in a tissue-specific manner PMID: 23226525
    10. Odz4 is expressed in quiescent satellite cells, like calcitonin receptor, but the timing of the reappearance of these genes is different during regeneration. PMID: 22562803
    11. The perinatal expression of CTR within the ENS suggests that the calcitonin/CTR system may have a role in the maturation of enteric neurons PMID: 22271140
    12. CGRP-receptor component protein has been found to interact only with calcitonin-like receptor and represents a novel neuroendocrine regulatory step in calcitonin gene-related peptide signaling. PMID: 22315449
    13. CTR protects against hypercalcemia predominantly via its inhibitory action on osteoclasts. PMID: 20850575
    14. Data show that amylin inactivation leads to a low bone mass due to an increase in bone resorption, whereas bone formation is unaffected. PMID: 14970190
    15. Calcr is imprinted in a tissue-specific manner, with a predominant expression from the maternal allele in the brain PMID: 12730726
    16. Data show that mutation of calcitonin-like receptor did not affect its expression at the cell surface, but impaired the calcitonin gene-related peptide and adrenomedullin receptor function in the presence of receptor-activity-modifying proteins 1 and 2. PMID: 15194494
    17. CTR is not only down regulated by signaling through the CTR but also by the peptides signaling through calcitonin receptor-like receptor, and receptor activity modifying proteins PMID: 18384073
    18. These data provide strong evidence for a biological role of the CTR in regulating calcium homeostasis in states of calcium stress. PMID: 18627265

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  • 亞細胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    G-protein coupled receptor 2 family
  • 數(shù)據庫鏈接：