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Recombinant Mouse Carnitine O-palmitoyltransferase 1, brain isoform (Cpt1c)

  • 中文名稱：
    Recombinant Mouse Carnitine O-palmitoyltransferase 1, brain isoform(Cpt1c)
  • 貨號：
    CSB-CF804322MO
  • 規(guī)格：
  • 來源：
    in vitro E.coli expression system
  • 其他：

產品詳情

  • 基因名：
  • Uniprot No.：
  • 別名：
    Cpt1c; Carnitine O-palmitoyltransferase 1, brain isoform; CPT1-B; CPT IC; Carnitine O-palmitoyltransferase I, brain isoform; CPTI-B; Carnitine palmitoyltransferase 1C
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    full length protein
  • 表達區(qū)域：
    1-798
  • 氨基酸序列
    MAEAHQASSLLSSLSSDGAEVELSSPVWQEIYLCALRSWKRHLWRVWNDFLAGVVPATPL SWLFLFSTIQLACLLQLDPSLGLMEKIKELLPDWGGQHHQLQGFLSAAVFASCLWGALIF TLHVALRLLLSHHGWLLEPHGAMSSPTKTWLALVRIFSGRHPRLFSFQRALPRQPVPSAQ ETVRKYLESVRPVLGDDAFDRATALANDFLRLHAPRLQLYLQLKSWCTSNYVSDWWEEFV YLRSRGSLINSTYYMMDFLYVTPTPLQAARAGNAVHTLLLYRHLLNRQEISPTLLMGMRP LCSAQYERMFNTTRIPGVEKDHLRHLQDSRHVAVFHRGRFFRVGTHSPNGLLSPRALEQQ FQDILDDPSPACPLEEHLAALTAAPRSMWAQVRESVKTHAATALEAVEGAAFFVSLDSEP AGLTREDPAASLDAYAHALLAGRGHDRWFDKSFTLIVFSNGKLGLSVEHSWADCPVSGHL WEFTLATECFQLGYATDGHCKGHPDPTLPQPQRLQWDLPEQIQPSISLALRGAKTLSGNI DCHVFPFSHFGKSFIKCCHVSSDSFIQLVLQLAHFRDRGQFCLTYESAMTRLFLEGRTET VRSCTREACQFVRAMDNKETDQHCLALFRVAVDKHQALLKAAMSGQGIDRHLFALYIMSR LLHMQSPFLTQVQSQQWLLSTSQVPVQQTHLIDVHNYPDYVSSGGGFGPAHDHGYGISYI FMGENAITFHISSKKSSTETDSHRLGQHIENALLDVASLFRVGQHFKRQFRGENSDYRYN FLSCKTVDPNTPTSSTNL
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白標簽：
    N-terminal 10xHis-tagged
  • 產品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    May play a role in lipid metabolic process.
  • 基因功能參考文獻：
    1. CPT1C in the mediobasal hypothalamus is necessary for proper hypothalamic sensing of a negative energy balance and fuel partitioning in liver and muscle. PMID: 28472467
    2. data newly identify CPT1C as a regulator of AMPAR translation efficiency and therefore also synaptic function in the hippocampus PMID: 26338711
    3. Results indicate that altered ceramide metabolism in motor brain areas induced by Cpt1c deficiency causes progressive motor dysfunction from a young age PMID: 23973755
    4. The expression of CPT1C is induced by metabolic stress factors such as hypoxia and glucose deprivation in a p53 and AMP activated kinase-dependent manner. PMID: 23412344
    5. ghrelin induces food intake through regulation of hypothalamic CPT1C and ceramide metabolism PMID: 23493572
    6. CPT1c is not involved in fatty acid beta-oxidation, there were no changes in metabolites associated with fatty acid oxidation. PMID: 23098614
    7. CPT1C regulates the levels of ceramide in the endoplasmic reticulum of hippocampal neurons PMID: 22539351
    8. CPT1c can elicit profound effects on brain physiology and total fatty acid profiles, which can be modulated by the nutritional composition of the diet PMID: 21592121
    9. Data show that the anorectic actions of central leptin or cerulenin are impaired in mice with brain CPT-1c deleted. PMID: 21593415
    10. cells can use a novel mechanism involving CPT1C and fatty acid metabolism to protect against metabolic stress PMID: 21576264
    11. CPT1c is necessary for the regulation of energy homeostasis PMID: 16651524
    12. CPT1c is appropriately localized in regions and cell types to regulate energy homeostasis PMID: 17559810
    13. Plays a role in maintaining energy homeostasis, but not through altered fatty acid oxidation. PMID: 18248603
    14. Changes in hepatic and skeletal muscle glucose metabolism are important mechanisms determining the phenotype of Cpt1c knockout mice, rendering them susceptible to glucose intolerance. PMID: 19224198

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  • 亞細胞定位：
    Mitochondrion outer membrane; Multi-pass membrane protein. Cell junction, synapse. Cell projection, axon. Cell projection, dendrite. Endoplasmic reticulum.
  • 蛋白家族：
    Carnitine/choline acetyltransferase family
  • 組織特異性：
    Predominantly expressed in brain (at protein level) and testis. Expressed in motor neurons. Expressed in the ventral horn from spinal cords.
  • 數(shù)據(jù)庫鏈接：