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Recombinant Mouse Phosphoinositide-interacting protein (Pirt)

  • 中文名稱：
    小鼠Pirt重組蛋白
  • 貨號：
    CSB-CF803844MO
  • 規(guī)格：
  • 來源：
    in vitro E.coli expression system
  • 其他：

產(chǎn)品詳情

  • 基因名：
    Pirt
  • Uniprot No.：
  • 別名：
    Pirt; Phosphoinositide-interacting protein
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    full length protein
  • 表達(dá)區(qū)域：
    1-135
  • 氨基酸序列
    MEVLPKALEVDERSPESKDLLPSQTASSLCISSRSESVWTTTPKSNWEIYHKPIIIMSVG AAILLFGVAITCVAYILEEKHKVVQVLRMIGPAFLSLGLMMLVCGLVWVPIIKKKQKQRQ KSNFFQSLKFFLLNR
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白標(biāo)簽：
    N-terminal 10xHis-tagged
  • 產(chǎn)品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    Regulatory subunit of TRPV1, a molecular sensor of noxious heat and capsaicin. Positively regulates TRPV1 channel activity via phosphatidylinositol 4,5-bisphosphate (PIP2). Binds various phosphoinositide, including phosphatidylinositol 4,5-bisphosphate (PIP2), but not phosphatidylinositol (PI).
  • 基因功能參考文獻(xiàn)：
    1. Results show that mechanical allodynia and thermal hyperalgesia were alleviated in Pirt-/- mice in chronic constriction injury (CCI) model. Taken together, Pirt together with transient receptor potential vanilloid channel 1 is involved in CCI-induced neuropathic pain. PMID: 29808083
    2. Pirt regulates TRPM8 channel activity by increasing the single channel conductance. PMID: 26657057
    3. These results demonstrate that Pirt is an endogenous regulator of P2X3 in bladder function. PMID: 26151598
    4. Pirt plays an important role in mice uterine contraction-induced pain. PMID: 26376721
    5. Pirt contributes to both histaminergic and nonhistaminergic itch and, crucially, is involved in forms of itch that are both TRPV1-dependent and -independent. PMID: 21655234
    6. Pirt is a key component of the TRPV1 complex and positively regulates TRPV1 activity. PMID: 18455988

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  • 亞細(xì)胞定位：
    Membrane; Multi-pass membrane protein.
  • 組織特異性：
    Strongly expressed in most dorsal root ganglia (DRG) and trigeminal neurons. Expressed by most peptidergic (CGRP+) and non-peptidergic (IB4+) DRG neurons. Weakly expressed in other parts of the peripheral nervous system (PNS) including sympathetic and ent
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