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Recombinant Rat Gap junction beta-2 protein (Gjb2)

  • 中文名稱：
    大鼠Gjb2重組蛋白
  • 貨號(hào)：
    CSB-CF009452RA
  • 規(guī)格：
  • 來(lái)源：
    in vitro E.coli expression system
  • 其他：

產(chǎn)品詳情

  • 基因名：
  • Uniprot No.：
  • 別名：
    Gjb2; Cxn-26; Gap junction beta-2 protein; Connexin-26; Cx26
  • 種屬：
    Rattus norvegicus (Rat)
  • 蛋白長(zhǎng)度：
    Full length protein
  • 表達(dá)區(qū)域：
    1-226
  • 氨基酸序列
    MDWGTLQSILGGVNKHSTSIGKIWLTVLFIFRIMILVVAAKEVWGDEQADFVCNTLQPGC KNVCYDHYFPISHIRLWALQLIMVSTPALLVAMHVAYRRHEKKRKFMKGEIKNEFKDIEE IKTQKVRIEGSLWWTYTTSIFFRVIFEAVFMYVFYIMYNGFFMQRLVKCNAWPCPNTVDC FISRPTEKTVFTVFMISVSGICILLNITELCYLFIRYCSGKSKRPV
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白標(biāo)簽：
    N-terminal 10xHis-tagged
  • 產(chǎn)品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 儲(chǔ)存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Structural component of gap junctions. Gap junctions are dodecameric channels that connect the cytoplasm of adjoining cells. They are formed by the docking of two hexameric hemichannels, one from each cell membrane. Small molecules and ions diffuse from one cell to a neighboring cell via the central pore.
  • 基因功能參考文獻(xiàn)：
    1. These results demonstrate that chronic prenatal hypoxia caused hearing impairment, and suggest that promoter region hypermethylation and expression downregulation of Cx26 underlie the mechanism of action PMID: 29207085
    2. Reduced expression of Connexin26 and its DNA promoter hypermethylation in the inner ear of mimetic aging rats might contribute to the development of presbycusis. PMID: 25159847
    3. the surface topography of Cx26 hemichannels PMID: 25365227
    4. Increased expression of connexin 26 protein and mRNA expression in the cochlear lateral wall were detected 3 h after the single injection of gentamicin. PMID: 22896926
    5. Changes in Cx43 expression following engraftment of neural stem cells to striatal tissue. PMID: 20654614
    6. T135 and P87 residues are in positions that are important for connexin26 oligomer stability and can affect gap junction gating. PMID: 20441744
    7. Data show that knowledge of the PTMs of Cx26 will be instrumental in understanding how alterations in the cellular mechanisms of Cx26 channel biogenesis and function lead to losses in auditory function and disfiguring skin disorders. PMID: 19775242
    8. Data show that mechanical stress of urothelial cells activates in vivo JNK, as a consequence of a regulated expression of IB1/JIP-1, and that urothelial connexin 26 may be directly regulated by the AP-1 complex [connexin 26]. PMID: 12064607
    9. Data show that connexins are differentially expressed in rat gray matter: Cx26, Cx30 and Cx43 were found only in astrocyte gap junctions; Cx32 was only in oligodendrocytes, and Cx36 was only in neurons [connexin 26] PMID: 12064610
    10. We report the identification of a novel Cx26 point mutation (439 G-->A) linked to familial, autosomal recessive, sensorineural hearing loss. PMID: 14676473
    11. Endometrial expression of Cx26 and Cx43 is induced via estrogen and ERalpha during preimplantation but then utilizes an estrogen receptor-independent signaling pathway during embryo implantation and decidualization. PMID: 15028626
    12. Cx26 forms gap junctions, but not heterotrimeric channels in co-expressing cells. PMID: 15128867
    13. Aberrant methylation of the Cx26 gene may be involved in the development of lung adenocarcinomas induced by N-nitrosobis(2-hydroxypropyl)amine in rats. PMID: 16637067
    14. Cx43 and Cx26 collectively co-regulate epidermal differentiation from basal keratinocytes but play a more minimal role in the maintenance of established epidermis PMID: 17693411
    15. the gap junction subunits connexin 26 (Cx26) and connexin 43 (Cx43) are expressed at the contact points between radial fibres and migrating neurons, and acute downregulation of Cx26 or Cx43 impairs the migration of neurons to the cortical plate PMID: 17713529
    16. increased CX26 expression is associated with differentiation of keratinocytes PMID: 19194037

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  • 亞細(xì)胞定位：
    Cell membrane; Multi-pass membrane protein. Cell junction, gap junction.
  • 蛋白家族：
    Connexin family, Beta-type (group I) subfamily
  • 組織特異性：
    Liver, kidney, intestine, lung, spleen, stomach, testis and brain, but not heart and adult skeletal muscle.
  • 數(shù)據(jù)庫(kù)鏈接：