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  4. Recombinant Rat Somatostatin receptor type 3 (Sstr3)

Recombinant Rat Somatostatin receptor type 3 (Sstr3)

  • 中文名稱：
    大鼠Sstr3重組蛋白
  • 貨號(hào)：
    CSB-CF022726RA
  • 規(guī)格：
  • 來(lái)源：
    in vitro E.coli expression system
  • 其他：

產(chǎn)品詳情

  • 基因名：
    Sstr3
  • Uniprot No.：
  • 別名：
    Sstr3; Somatostatin receptor type 3; SS-3-R; SS3-R; SS3R; SSR-28
  • 種屬：
    Rattus norvegicus (Rat)
  • 蛋白長(zhǎng)度：
    Full length protein
  • 表達(dá)區(qū)域：
    1-428
  • 氨基酸序列
    MAAVTYPSSVPTTLDPGNASSAWPLDTSLGNASAGTSLAGLAVSGILISLVYLVVCVVGL LGNSLVIYVVLRHTSSPSVTSVYILNLALADELFMLGLPFLAAQNALSYWPFGSLMCRLV MAVDGINQFTSIFCLTVMSVDRYLAVVHPTRSARWRTAPVARMVSAAVWVASAVVVLPVV VFSGVPRGMSTCHMQWPEPAAAWRTAFIIYTAALGFFGPLLVICLCYLLIVVKVRSTTRR VRAPSCQWVQAPACQRRRRSERRVTRMVVAVVALFVLCWMPFYLLNIVNVVCPLPEEPAF FGLYFLVVALPYANSCANPILYGFLSYRFKQGFRRILLRPSRRVRSQEPGSGPPEKTEEE EDEEEEERREEEERRMQRGQEMNGRLSQIAQPGPSGQQQRPCTGTAKEQQLLPQEATAGD KASTLSHL
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白標(biāo)簽：
    N-terminal 10xHis-tagged
  • 產(chǎn)品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 儲(chǔ)存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Receptor for somatostatin-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase.
  • 基因功能參考文獻(xiàn)：
    1. In the jejunums of Cryptosporidium-parvum-infected rats, daily octreotide therapy increased mRNA levels of SSTR3 on day 50 post-infection. Specific SSTRs may regulate the inflammatory pathway in the rat intestinal inflammation model. PMID: 29522573
    2. SSTR3 was significantly up-regulated after intracerebral hemorrhage, along with neuronal apoptosis. PMID: 28176050
    3. identification of a plasma membrane targeting sequence of rat somatostatin receptor subtype 3 [somatostatin receptor 3] PMID: 11935411
    4. SST-14 was cointernalized with SSTR3, was uncoupled from receptor, & was sorted into an endocytic degradation pathway, whereas octreotide was recycled as an intact peptide. Chronic stimulation of SSTR3 induced time-dependent downregulation of receptor. PMID: 18702662
    5. the R-type calcium channel does not mediate the effects of somatostatin receptor 3 on insulin secretion in INS-1 cells. PMID: 18793718
    6. study examined embryonic & postnatal development of SSTR3 expression in the hippocampal formation & its association with newly born & mature neurons in adult rats PMID: 18992731

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  • 亞細(xì)胞定位：
    Cell membrane; Multi-pass membrane protein. Note=Internalized into endoplasmic vesicles upon somatostatin-stimulation.
  • 蛋白家族：
    G-protein coupled receptor 1 family
  • 組織特異性：
    Densely expressed in cerebellum and at moderate levels in the amygdala, cortex, striatum, spleen, liver and pituitary.
  • 數(shù)據(jù)庫(kù)鏈接：