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Recombinant Rat Stromal interaction molecule 1 (Stim1)

  • 中文名稱：
    大鼠Stim1重組蛋白
  • 貨號：
    CSB-CF022829RA
  • 規(guī)格：
  • 來源：
    in vitro E.coli expression system
  • 其他：

產(chǎn)品詳情

  • 基因名：
  • Uniprot No.：
  • 別名：
    Stim1; Sim; Stromal interaction molecule 1
  • 種屬：
    Rattus norvegicus (Rat)
  • 蛋白長度：
    Full Length of Mature Protein
  • 表達區(qū)域：
    23-685
  • 氨基酸序列
    LSHSHSEKNTGASSGATSEESTEAEFCRIDKPLCHSEDEKLSFEAVRNIHKLMDDDANGDVDVEESDEFLREDLNYHDPTVKHSTFHGEDKLISVEDLWKAWKASEVYNWTVDEVIQWLITYVELPQYEETFRKLQLTGHAMPRLAVTNTTMTGTVLKMTDRSHRQKLQLKALDTVLFGPPLLTRHNHLKDFMLVVSIVIGVGGCWFAYIQNRYSKEHMKKMMKDLEGLHRAEQSLHDLQERLHKAQEEHRTVEVEKVHLEKKLRDEINLAKQEAQRLKELREGTENERSRQKYAEEELEQVREALRKAEKELESHSSWYAPEALQKWLQLTHEVEVQYYNIKKQNAERQLLVAKEGAEKIKKKRNTLFGTFHVAHSSSLDDVDHKILTAKQALSEVTAALRERLHRWQQIEILCGFQIVNNPGIHSLVAALNIDPSWMGSTRPNPAHFIMTDDVDDMDEEIVSPLSMQSPSLQSSVRQRLTEPQHGLGSQRDLTHSDSESSLHTSDRQRVAPKPPQMGRAADEALNATSSNGSHRLIEGVHPGSLVEKLPDSPALAKKTILALNHGLDKAHSLMELNPSVPPGGSPLLDSSHSHSPSSPDPDTPSPVGDSRALQGSRNTRIPHLAGKKAMAEEDNGSIGEETDSSPGRKKFPLKIFKKPLKK
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白標(biāo)簽：
    N-terminal 10xHis-tagged
  • 產(chǎn)品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Acts as Ca(2+) sensor in the endoplasmic reticulum via its EF-hand domain. Upon Ca(2+) depletion, translocates from the endoplasmic reticulum to the plasma membrane where it activates the Ca(2+) release-activated Ca(2+) (CRAC) channel subunit ORAI1. Involved in enamel formation. Activated following interaction with STIMATE, leading to promote STIM1 conformational switch.
  • 基因功能參考文獻：
    1. Suppression of STIM1 reduced intracellular calcium level and attenuated hypoxia/reoxygenation induced apoptosis in H9C2 cardiomyocytes. PMID: 29089467
    2. downregulation of miR-223 by phenylephrine contributed to the increase of STIM1, which in turn induced cardiac hypertrophy. PMID: 29110214
    3. STIM1 may play an important role in the pathogenesis of alcoholic liver disease. PMID: 29704510
    4. The function of STIM1 in the regulation of the store-operated Ca(2+)-entry in astrocytes PMID: 27237974
    5. that sub-lethal levels of proteasome inhibition reduce store-operated calcium entry and promote autophagy-mediated degradation of STIM1 and STIM2 PMID: 26960935
    6. STIM1 binding to phospholamban contributes to the regulation of SERCA2a activity in the steady state and rate of SR Ca(2+) leak and that these actions are independent of store-operated Ca(2+) entry, a process that is absent in normal heart cells PMID: 26261328
    7. Studied the effect of STIM1 knockdown on the proliferation and migration of endothelial progenitor cells (EPCs) after vascular injury and its mechanism. PMID: 25063063
    8. Knockdown of STIM1 blocked degradation of Sp4, whereas expression of constitutively active STIM1 decreased Sp4 abundance under depolarizing conditions. PMID: 24894994
    9. Our results suggested that Stim1 is a strong candidate gene responsible for the exaggerated sympathetic response to stress in SHRSP. PMID: 24736434
    10. This study demonistrated that inhibition of stim1 expression and decreased the intracellular calcium concentration in neurons. PMID: 24509424
    11. Experimental subarachnoid hemorrhage significantly increased mRNA and protein expressions of STIM1 in rats. PMID: 23542055
    12. Silencing of STIM1 significantly decreases cellular proliferation and delayed cell cycle progression induced by hypoxia. PMID: 23289723
    13. These results indicate enhanced STIM1 expression due to diffuse axonal injury PMID: 23261659
    14. The overexpression of STIM1 increased by twofold the Ca(2+) influx evoked by thrombin, while knockdown of endogenous STIM1 significantly decreased this Ca(2+) influx. PMID: 22944608
    15. Modification of STIM1 by O-linked N-acetylglucosamine (O-GlcNAc) attenuates store-operated calcium entry in neonatal cardiomyocytes PMID: 22992728
    16. STIM1 is essential for correct growth cone navigation and plays multiple roles in growth cone motility, including activation of store-operated calcium entry (SOCE). PMID: 22712562
    17. By controlling a previously unrecognized sarcolemmal current, STIM1 promotes cardiac hypertrophy. PMID: 21810664
    18. STIM1 is a potent regulator of cell proliferation and migration in rat endothelial progenitor cells (EPCs) and may play an important role in the biological properties of EPCs. PMID: 20599714
    19. HGF-induced EPC proliferation is mediated partly via activation of STIM1 PMID: 20404049
    20. proposal that STIM1 functions as the missing link between Ca2+ store depletion and store-operated calcium influx, serving as a Ca2+ sensor that translocates upon store depletion to the plasma membrane to activate CRAC channels PMID: 16208375
    21. suppression of store-operated channels function by Orai1 overexpression likely reflects a required stoichiometry between STIM1 and Orai1 PMID: 16766533
    22. Knockdown of STIM1 (stromal interaction molecule type 1) by siRNA also resulted in a significant reduction (approx. 80% at 72 h post-transfection) of the I(SOC) amplitude. PMID: 17432954
    23. Differences in STIM1 and TRPC expression in proximal and distal pulmonary arterial smooth muscle are associated with differences in Ca2+ responses to hypoxia.( PMID: 18424621
    24. Knockdown of Stim1 inhibits endothelial proliferation and causes cell cycle arrest at S and G2/M phase. PMID: 18845811
    25. Results suggest STIM1 has a critical role in neointimal formation in a rat model of vascular injury. PMID: 19052075
    26. STIM1 appears as a major regulator of in vitro and in vivo vascular smooth muscle cell proliferation, representing a novel and original pharmacological target for prominent vascular proliferative diseases PMID: 19107116
    27. STIM1 was quantitatively more important than STIM2 in activation of store-operated channels in rat distal pulmonary arterial smooth muscle cells. PMID: 19395668

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  • 亞細胞定位：
    Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein. Sarcoplasmic reticulum. Cytoplasm, cytoskeleton.
  • 數(shù)據(jù)庫鏈接：