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ACVR2B

ACVR2B,即激活素A型II型受體B,它是一種由ACVR2B基因編碼的跨膜絲氨酸/蘇氨酸激酶受體,屬于TGF-β超家族成員之一。ACVR2B在多種組織中表達(dá),尤其在腫瘤細(xì)胞上的表達(dá)水平較高。其作用機(jī)制涉及與激活素A結(jié)合后,招募并磷酸化I型激活素受體,通過(guò)SMAD2/3蛋白發(fā)出信號(hào),進(jìn)而調(diào)節(jié)細(xì)胞的增殖、分化和遷移。ACVR2B參與的信號(hào)通路包括與ALK4或ALK7等I型受體的相互作用,影響多種生物學(xué)過(guò)程。在生物學(xué)意義上,ACVR2B的表達(dá)水平與腫瘤生長(zhǎng)、轉(zhuǎn)移性以及治療反應(yīng)密切相關(guān),是腫瘤治療和預(yù)后評(píng)估的重要生物標(biāo)志物。

熱銷(xiāo)產(chǎn)品

Recombinant Human Activin receptor type-2B (ACVR2B), partial (CSB-YP623829HU)

驗(yàn)證數(shù)據(jù)

CSB-YP623829HU

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

ACVR2B Recombinant Monoclonal Antibody (CSB-RA260702A0HU)

驗(yàn)證數(shù)據(jù)

CSB-RA260702A0HU

IHC image of CSB-RA260702A0HU diluted at 1:100 and staining in paraffin-embedded human breast cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.

CSB-RA260702A0HU

IHC image of CSB-RA260702A0HU diluted at 1:100 and staining in paraffin-embedded human placenta tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.

ACVR2B Antibodies

ACVR2B for Homo sapiens (Human)

ACVR2B Proteins

ACVR2B Proteins for Mus musculus (Mouse)

ACVR2B Proteins for Rattus norvegicus (Rat)

ACVR2B Proteins for Xenopus laevis (African clawed frog)

ACVR2B Proteins for Homo sapiens (Human)

ACVR2B Proteins for Sus scrofa (Pig)

ACVR2B Proteins for Gallus gallus (Chicken)

ACVR2B Proteins for Bos taurus (Bovine)