Your Good Partner in Biology Research

ADGRE2

ADGRE2,即粘附G蛋白偶聯(lián)受體E2,別名GPR124和TEM5。它是一種細胞表面受體,屬于粘附G蛋白偶聯(lián)受體家族成員,由ADGRE2基因編碼。ADGRE2在多種細胞類型中表達,尤其在腫瘤血管內(nèi)皮細胞中,通過與細胞外基質(zhì)分子相互作用,參與細胞黏附和遷移等過程。其作用機制涉及激活G蛋白偶聯(lián)的信號通路,進而調(diào)節(jié)細胞內(nèi)鈣離子濃度和蛋白激酶活性。ADGRE2在腫瘤治療中的潛在靶點角色,以及與振動性蕁麻疹等免疫相關(guān)疾病的關(guān)聯(lián)。異常的ADGRE2表達可能與腫瘤微環(huán)境的調(diào)節(jié)和腫瘤免疫治療的效果有關(guān),是當前藥物開發(fā)和疾病治療研究中的一個關(guān)注點。

熱銷產(chǎn)品

ADGRE2 Antibody (CSB-PA887050LA01HU)

驗證數(shù)據(jù)

CSB-PA887050LA01HU

IHC image of CSB-PA887050LA01HU diluted at 1:500 and staining in paraffin-embedded human lymph node tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

CSB-PA887050LA01HU

IHC image of CSB-PA887050LA01HU diluted at 1:500 and staining in paraffin-embedded human spleen tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

CSB-PA887050LA01HU

Immunofluorescence staining of Hela cells with CSB-PA887050LA01HU at 1:166, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

ADGRE2 Antibodies

ADGRE2 for Homo sapiens (Human)

ADGRE2 Proteins

ADGRE2 Proteins for Macaca mulatta (Rhesus macaque)

ADGRE2 Proteins for Canis familiaris (Dog) (Canis lupus familiaris)

ADGRE2 Proteins for Homo sapiens (Human)