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ALDH1A2

ALDH1A2,即醛脫氫酶1家族成員A2,別名DIH4、RALDH2、RALDH2-T、RALDH(II)等。這是一種由人類基因編碼的酶,主要參與視黃醇代謝的第二步,將視黃醛不可逆地氧化成視黃酸,是視黃酸的主要合成酶 。視黃酸是維生素A的活性衍生物,作為一種激素信號(hào)分子,在發(fā)育和成人組織中發(fā)揮作用,對(duì)胚胎發(fā)育和成體組織的維持至關(guān)重要 。ALDH1A2在生物學(xué)上的意義主要體現(xiàn)在其對(duì)視黃酸水平的調(diào)控作用。研究表明,ALDH1A2與細(xì)胞色素CYP26A1共同作用,建立局部胚胎視黃酸水平,促進(jìn)后部器官的發(fā)育并預(yù)防脊柱裂的發(fā)生 。ALDH1A2的異常表達(dá)與多種疾病相關(guān),包括神經(jīng)管缺陷、小眼癥、膈疝等 。此外,ALDH1A2在某些腫瘤干細(xì)胞中的表達(dá)增加,可能與腫瘤的發(fā)生發(fā)展有關(guān) 。因此,ALDH1A2是藥物開發(fā)和疾病治療中的一個(gè)潛在靶點(diǎn)。

熱銷產(chǎn)品

Recombinant Human Retinal dehydrogenase 2 (ALDH1A2) (CSB-YP001566HU)

驗(yàn)證數(shù)據(jù)

CSB-YP001566HU

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

ALDH1A2 Antibody (CSB-PA001566EA01HU)

驗(yàn)證數(shù)據(jù)

CSB-PA001566EA01HU

Western Blot
Positive WB detected in: K562 whole cell lysate, Mouse kidney tissue
All lanes: ALDH1A2 antibody at 3.5µg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 57, 54, 55, 47 kDa
Observed band size: 54 kDa

CSB-PA001566EA01HU

Immunohistochemistry of paraffin-embedded human lung tissue using CSB-PA001566EA01HU at dilution of 1:100

CSB-PA001566EA01HU

Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA001566EA01HU at dilution of 1:100

ALDH1A2 Antibodies

ALDH1A2 for Homo sapiens (Human)

ALDH1A2 Proteins

ALDH1A2 Proteins for Homo sapiens (Human)