ALDH1A2
ALDH1A2，即醛脫氫酶1家族成員A2，別名DIH4、RALDH2、RALDH2-T、RALDH(II)等。這是一種由人類基因編碼的酶，主要參與視黃醇代謝的第二步，將視黃醛不可逆地氧化成視黃酸，是視黃酸的主要合成酶 。視黃酸是維生素A的活性衍生物，作為一種激素信號(hào)分子，在發(fā)育和成人組織中發(fā)揮作用，對(duì)胚胎發(fā)育和成體組織的維持至關(guān)重要 。ALDH1A2在生物學(xué)上的意義主要體現(xiàn)在其對(duì)視黃酸水平的調(diào)控作用。研究表明，ALDH1A2與細(xì)胞色素CYP26A1共同作用，建立局部胚胎視黃酸水平，促進(jìn)后部器官的發(fā)育并預(yù)防脊柱裂的發(fā)生 。ALDH1A2的異常表達(dá)與多種疾病相關(guān)，包括神經(jīng)管缺陷、小眼癥、膈疝等 。此外，ALDH1A2在某些腫瘤干細(xì)胞中的表達(dá)增加，可能與腫瘤的發(fā)生發(fā)展有關(guān) 。因此，ALDH1A2是藥物開發(fā)和疾病治療中的一個(gè)潛在靶點(diǎn)。
熱銷產(chǎn)品
Recombinant Human Retinal dehydrogenase 2 (ALDH1A2) (CSB-YP001566HU)
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
ALDH1A2 Antibody (CSB-PA001566EA01HU)
驗(yàn)證數(shù)據(jù)
Western Blot
Positive WB detected in: K562 whole cell lysate, Mouse kidney tissue
All lanes: ALDH1A2 antibody at 3.5µg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 57, 54, 55, 47 kDa
Observed band size: 54 kDa
Immunohistochemistry of paraffin-embedded human lung tissue using CSB-PA001566EA01HU at dilution of 1:100
Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA001566EA01HU at dilution of 1:100
ALDH1A2 Antibodies
ALDH1A2 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA001566GA01HU | ALDH1A2 Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA001566ESR1HU | ALDH1A2 Antibody | Human, Mouse | ELISA, WB, IHC |
| CSB-PA001566ESR2HU | ALDH1A2 Antibody | Human, Mouse | ELISA, WB |
| CSB-PA144510 | ALDH1A2 Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA070161 | ALDH1A2 Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
| CSB-PA053602 | ALDH1A2 Antibody | Human,Mouse,Rat | ELISA,IHC |
| CSB-PA039662 | ALDH1A2 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA001566EA01HU | ALDH1A2 Antibody | Human, Mouse | ELISA, WB, IHC |
| CSB-PA001566ED01HU | ALDH1A2 Antibody, Biotin conjugated | Human | ELISA |
ALDH1A2 Proteins
ALDH1A2 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP001566HU | Recombinant Human Retinal dehydrogenase 2 (ALDH1A2) | Yeast |
| CSB-EP001566HU CSB-BP001566HU CSB-MP001566HU CSB-EP001566HU-B |
Recombinant Human Retinal dehydrogenase 2 (ALDH1A2) | E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
