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ATF4

ATF4,即激活轉(zhuǎn)錄因子4,別名CREB-2。ATF4是一種堿性區(qū)域亮氨酸拉鏈轉(zhuǎn)錄因子,屬于bZIP家族成員,由人類基因組中的ATF4基因編碼。它在細(xì)胞對(duì)多種應(yīng)激反應(yīng)的調(diào)控中發(fā)揮關(guān)鍵作用,包括氨基酸缺乏、氧化應(yīng)激和內(nèi)質(zhì)網(wǎng)應(yīng)激等。ATF4的作用機(jī)制主要是通過(guò)結(jié)合到目標(biāo)基因的啟動(dòng)子區(qū)域上的cAMP響應(yīng)元件(CRE)或相關(guān)的DNA序列,調(diào)節(jié)下游基因的轉(zhuǎn)錄。ATF4在生物學(xué)上的意義主要體現(xiàn)在其對(duì)細(xì)胞代謝、存活和應(yīng)激反應(yīng)的調(diào)控。它參與調(diào)節(jié)氨基酸代謝、抗氧化反應(yīng)、蛋白質(zhì)折疊和損傷修復(fù)等過(guò)程。在內(nèi)質(zhì)網(wǎng)應(yīng)激時(shí),ATF4能夠激活未折疊蛋白反應(yīng)(UPR),幫助細(xì)胞恢復(fù)蛋白質(zhì)穩(wěn)態(tài)。此外,ATF4還參與調(diào)節(jié)細(xì)胞周期、細(xì)胞凋亡以及自噬等過(guò)程,影響細(xì)胞的命運(yùn)。ATF4的功能異常與多種疾病相關(guān),包括代謝性疾病、神經(jīng)退行性疾病和某些類型的癌癥,因此,它也是藥物開(kāi)發(fā)中的一個(gè)潛在靶點(diǎn)。

熱銷產(chǎn)品

Recombinant Rat Cyclic AMP-dependent transcription factor ATF-4 (Atf4) (CSB-EP880648RA)

驗(yàn)證數(shù)據(jù)

CSB-EP880648RA

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

ATF4 Antibody (CSB-PA002272KA01HU)

驗(yàn)證數(shù)據(jù)

CSB-PA002272KA01HU

Western blot analysis of extracts from mouse craniofacial and mouse gastrocnemius, using ATF4 antibody.

CSB-PA002272KA01HU

Immunohistochemistry of paraffin-embedded Breast cancer using ATF4 Antibody.

ATF4 Antibodies

ATF4 for Homo sapiens (Human)

ATF4 Proteins

ATF4 Proteins for Mus musculus (Mouse)

ATF4 Proteins for Homo sapiens (Human)

ATF4 Proteins for Bos taurus (Bovine)

ATF4 Proteins for Danio rerio (Zebrafish) (Brachydanio rerio)

ATF4 Proteins for Rattus norvegicus (Rat)