BCL9L
BCL9L,即B細(xì)胞淋巴瘤/白血病9樣蛋白,是一種與BCL9具有高度同源性的蛋白質(zhì)。BCL9L主要來(lái)源于基因的轉(zhuǎn)錄和翻譯過(guò)程,它在細(xì)胞核中發(fā)揮作用,參與調(diào)控基因表達(dá)。BCL9L的作用機(jī)制涉及到與β-catenin的相互作用,通過(guò)影響Wnt/β-catenin信號(hào)通路來(lái)調(diào)節(jié)細(xì)胞增殖和分化。在信號(hào)傳導(dǎo)方面,BCL9L與β-catenin結(jié)合后,可以促進(jìn)與TCF/LEF轉(zhuǎn)錄因子的復(fù)合體形成,激活Wnt信號(hào)通路的靶基因。BCL9L在腫瘤發(fā)展中可能起到促進(jìn)作用,尤其是在某些類(lèi)型的癌癥中,其過(guò)表達(dá)與腫瘤的侵襲性和預(yù)后不良相關(guān)。在生物學(xué)意義上,BCL9L不僅與腫瘤的發(fā)生發(fā)展有關(guān),還可能參與正常細(xì)胞的生理過(guò)程,如細(xì)胞周期調(diào)控和組織再生。由于其在Wnt信號(hào)通路中的作用,BCL9L也是藥物開(kāi)發(fā)和癌癥治療研究的潛在靶點(diǎn)。
熱銷(xiāo)產(chǎn)品
Recombinant Human B-cell CLL/lymphoma 9-like protein (BCL9L), partial
驗(yàn)證數(shù)據(jù)
來(lái)源:Yeast
來(lái)源:E.coli
來(lái)源:Baculovirus
來(lái)源:Mammalian cell
來(lái)源:In Vivo Biotinylation in E.coli
BCL9L Proteins
BCL9L Proteins for Danio rerio (Zebrafish) (Brachydanio rerio)
產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
---|---|---|
CSB-YP714938DIL CSB-EP714938DIL CSB-BP714938DIL CSB-MP714938DIL CSB-EP714938DIL-B |
Recombinant Danio rerio B-cell CLL/lymphoma 9-like protein (bcl9l), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
BCL9L Proteins for Mus musculus (Mouse)
產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
---|---|---|
CSB-YP717998MO CSB-EP717998MO CSB-BP717998MO CSB-MP717998MO CSB-EP717998MO-B |
Recombinant Mouse B-cell CLL/lymphoma 9-like protein (Bcl9l), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
BCL9L Proteins for Homo sapiens (Human)
產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
---|---|---|
CSB-YP769780HU CSB-EP769780HU CSB-BP769780HU CSB-MP769780HU CSB-EP769780HU-B |
Recombinant Human B-cell CLL/lymphoma 9-like protein (BCL9L), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |