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C5

C5,即補(bǔ)體成分5,別名C5α、C5b等。它是人類補(bǔ)體系統(tǒng)的一部分,由肝臟細(xì)胞產(chǎn)生,是一種血清蛋白。C5的作用機(jī)制主要是通過補(bǔ)體級聯(lián)反應(yīng)被激活,C5可以被C4b2a(經(jīng)典途徑和凝集素途徑)或C3bBb3b(旁路途徑)裂解為C5a和C5b兩個片段。C5a是一個具有強(qiáng)烈炎癥活性的小分子肽,能夠吸引和激活多種免疫細(xì)胞,如中性粒細(xì)胞和單核細(xì)胞,而C5b則啟動膜攻擊復(fù)合物(MAC)的形成,導(dǎo)致外來細(xì)胞的溶解。C5在生物學(xué)上的意義非常廣泛,它在天然免疫和獲得性免疫之間起著橋梁作用。C5的活化參與了清除病原體和受損細(xì)胞、調(diào)節(jié)炎癥反應(yīng)、促進(jìn)免疫細(xì)胞的趨化和活化等重要過程。C5a-C5aR1信號通路在多種炎癥性疾病中發(fā)揮作用,包括結(jié)直腸癌等腫瘤的發(fā)展,通過影響免疫微環(huán)境和細(xì)胞內(nèi)信號傳導(dǎo)來促進(jìn)腫瘤的發(fā)生和發(fā)展。C5的異?;罨c多種自身免疫性疾病和炎癥性疾病的發(fā)生發(fā)展密切相關(guān),因此,C5或其受體C5aR1已成為藥物開發(fā)的潛在靶點 。

熱銷產(chǎn)品

C5 Recombinant Monoclonal Antibody (CSB-RA003995MA1HU)

驗證數(shù)據(jù)

CSB-RA003995MA1HU

Overlay Peak curve showing Hela cells surface stained with CSB-RA003995MA1HU (red line) at 1:800. Then 10% normal goat serum was Incubated to block non-specific protein-protein interactions followed by the antibody (1μg/1*106cells) for 45 min at 4°C. The secondary antibody used was FITC-conjugated Goat Anti-Mouse IgG(H+L) at 1/200 dilution for 35 min at 4°C. Isotype control antibody (green line) was mouse IgG1 (1μg/1*106cells) used under the same conditions. Acquisition of >10, 021 events was performed.

C5 Antibodies

C5 for Pig

C5 for Homo sapiens (Human)

C5 Proteins

C5 Proteins for Bos taurus (Bovine)

C5 Proteins for Rattus norvegicus (Rat)

C5 Proteins for Sus scrofa (Pig)

C5 Proteins for Homo sapiens (Human)

C5 Proteins for Mus musculus (Mouse)

C5 ELISA Kit

C5 ELISA Kit for Mus musculus (Mouse)

C5 ELISA Kit for Rattus norvegicus (Rat)