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CARD14

CARD14,即胱冬酶吸引域家族成員14,別名PRP、PSORS2等,是MAGUK家族的一員。它源自人類基因,通過激活NF-κB信號通路,在免疫和炎癥反應(yīng)中發(fā)揮核心作用。CARD14尤其在皮膚細(xì)胞中表達(dá)豐富,對維護(hù)皮膚屏障及防御外界病原體至關(guān)重要。其異常激活與牛皮癬等皮膚疾病的發(fā)病緊密相關(guān),可能通過促進(jìn)角質(zhì)細(xì)胞增生和炎癥反應(yīng)導(dǎo)致疾病發(fā)生。因此,CARD14不僅是理解皮膚生物學(xué)和免疫調(diào)節(jié)機制的關(guān)鍵,也是開發(fā)針對皮膚疾病新療法的潛在靶點。

熱銷產(chǎn)品

CARD14 Antibody (CSB-PA883622LA01HU)

驗證數(shù)據(jù)

CSB-PA883622LA01HU

Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA883622LA01HU at dilution of 1:100

CSB-PA883622LA01HU

Immunohistochemistry of paraffin-embedded human placenta tissue using CSB-PA883622LA01HU at dilution of 1:100

CSB-PA883622LA01HU

Immunofluorescence staining of Hela cells with CSB-PA883622LA01HU at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

CARD14 Antibodies

CARD14 for Homo sapiens (Human)

CARD14 Proteins

CARD14 Proteins for Mus musculus (Mouse)

CARD14 Proteins for Homo sapiens (Human)