CARD14
CARD14，即胱冬酶吸引域家族成員14，別名PRP、PSORS2等，是MAGUK家族的一員。它源自人類基因，通過激活NF-κB信號通路，在免疫和炎癥反應(yīng)中發(fā)揮核心作用。CARD14尤其在皮膚細(xì)胞中表達(dá)豐富，對維護(hù)皮膚屏障及防御外界病原體至關(guān)重要。其異常激活與牛皮癬等皮膚疾病的發(fā)病緊密相關(guān)，可能通過促進(jìn)角質(zhì)細(xì)胞增生和炎癥反應(yīng)導(dǎo)致疾病發(fā)生。因此，CARD14不僅是理解皮膚生物學(xué)和免疫調(diào)節(jié)機制的關(guān)鍵，也是開發(fā)針對皮膚疾病新療法的潛在靶點。
熱銷產(chǎn)品
CARD14 Antibody (CSB-PA883622LA01HU)
驗證數(shù)據(jù)
Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA883622LA01HU at dilution of 1:100
Immunohistochemistry of paraffin-embedded human placenta tissue using CSB-PA883622LA01HU at dilution of 1:100
Immunofluorescence staining of Hela cells with CSB-PA883622LA01HU at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
CARD14 Antibodies
CARD14 for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA004517GA01HU | CARD14 Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA060134 | CARD14 Antibody | Human,Mouse | IHC, IF, ELISA |
| CSB-PA592611 | CARD14 Antibody | Human | ELISA,WB,IHC |
| CSB-PA448323 | CARD14 Antibody | Human,Mouse | ELISA,WB,IHC |
| CSB-PA883622LA01HU | CARD14 Antibody | Human | ELISA, IHC, IF |
CARD14 Proteins
CARD14 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP860374MO CSB-EP860374MO CSB-BP860374MO CSB-MP860374MO CSB-EP860374MO-B |
Recombinant Mouse Caspase recruitment domain-containing protein 14 (Card14) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CARD14 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP883622HU CSB-EP883622HU CSB-BP883622HU CSB-MP883622HU CSB-EP883622HU-B |
Recombinant Human Caspase recruitment domain-containing protein 14 (CARD14), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
