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CCR4

CCR4:Treg細胞上的關(guān)鍵趨化因子受體,有望成為新型腫瘤免疫治療靶點!

C-C趨化因子受體(C-C chemokine receptor type 4,CCR4),也稱為CD194,由包含7次跨膜結(jié)構(gòu)域的多肽鏈組成,屬于G蛋白偶聯(lián)受體家族。其含360個氨基酸,分子量約為41kD,主要表達于各種淋巴細胞和組織,其配體包括多種趨化因子。作為重要的趨化因子受體,CCR4與其它趨化因子配體產(chǎn)生結(jié)合,行使其功能,參與調(diào)控人類自身免疫疾病過程,主要包括特應(yīng)性皮炎、哮喘、皮膚T細胞淋巴瘤。過去,研究人員對趨化因子的認識限于在炎癥反應(yīng)中的趨化作用,然而越來越多的研究顯示,趨化因子結(jié)合其受體在腫瘤細胞的浸潤性生長,遠處轉(zhuǎn)移等行為中發(fā)揮重要作用。CCR4作為腫瘤轉(zhuǎn)移中關(guān)鍵的趨化因子受體,多項研究已證實,CCR4高表達與血液系統(tǒng)腫瘤以及惡性實體瘤的浸潤和預(yù)后密切相關(guān),靶向CCR4有望成為惡性腫瘤免疫治療的新策略。

CUSABIO-哺乳包膜VLPs平臺成功開發(fā)CCR4全長膜蛋白(7次跨膜),展示了完整生物活性。

Recombinant Human CCR4-VLPs 活性蛋白實驗驗證數(shù)據(jù)

High Specificity Validated by Western blot (WB)

CSB-MP004843HU is detected by Mouse anti-6*His monoclonal antibody.

Excellent Bioactivity Validated by Functional ELISA

Immobilized Human CCR4 at 10 μg/ml can bind Anti-CCR4 recombinant antibody (CSB-RA004843MA01HU), the EC50 is 362.3-630.8 ng/mL.

Correct Structure Validated
by TEM

The presence of VLP-like structures was confirmed by TEM.


CCR4 Antibodies

CCR4 for Homo sapiens (Human)

CCR4 Proteins

CCR4 Proteins for Homo sapiens (Human)

CCR4 Proteins for Mus musculus (Mouse)

CCR4 Proteins for Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)

CCR4 Proteins for Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181) (Aspergillus fischerianus)

CCR4 Proteins for Aspergillus niger (strain CBS 513.88 / FGSC A1513)

CCR4 Proteins for Enterocytozoon bieneusi (strain H348) (Microsporidian parasite)

CCR4 Proteins for Nosema ceranae (strain BRL01) (Microsporidian parasite)

CCR4 Proteins for Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)

CCR4 Proteins for Aspergillus terreus (strain NIH 2624 / FGSC A1156)

CCR4 Proteins for Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173) (Glume blotch fungus) (Septoria nodorum)

CCR4 Proteins for Coccidioides immitis (strain RS) (Valley fever fungus)

CCR4 Proteins for Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold)

CCR4 Proteins for Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)

CCR4 Proteins for Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)

CCR4 Proteins for Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)

CCR4 Proteins for Ustilago maydis (strain 521 / FGSC 9021) (Smut fungus)

CCR4 Proteins for Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii)

CCR4 Proteins for Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)

CCR4 Proteins for Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)

CCR4 Proteins for Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)

CCR4 Proteins for Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii)

CCR4 Proteins for Encephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite)

CCR4 Proteins for Canis familiaris (Dog) (Canis lupus familiaris)

CCR4 Proteins for Arabidopsis thaliana (Mouse-ear cress)

CCR4 Proteins for Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)