CD3E

CD3E，即T細(xì)胞受體復(fù)合物的CD3ε亞基，它是一種在T細(xì)胞表面表達(dá)的糖蛋白，由CD3E基因編碼。CD3E是T細(xì)胞受體（TCR）信號(hào)傳導(dǎo)復(fù)合物的一部分，與TCRαβ或TCRγδ亞單位非共價(jià)結(jié)合。其作用機(jī)制是在T細(xì)胞受體識(shí)別并結(jié)合到主要組織相容性復(fù)合物（MHC）呈遞的抗原肽時(shí)，CD3E與其他CD3分子協(xié)同，傳遞激活信號(hào)，導(dǎo)致T細(xì)胞的激活。信號(hào)通路涉及酪氨酸激酶的激活，如ζ鏈相關(guān)蛋白激酶76（ZAP-70），進(jìn)而激活下游的多種信號(hào)分子，包括磷脂酰肌醇3激酶（PI3K）、蛋白激酶C（PKC）和絲裂原激活蛋白激酶（MAPK）。這些信號(hào)通路最終導(dǎo)致T細(xì)胞增殖、分化和效應(yīng)功能的發(fā)展。在生物學(xué)意義上，CD3E對(duì)T細(xì)胞介導(dǎo)的免疫應(yīng)答至關(guān)重要，它參與調(diào)節(jié)細(xì)胞毒性T細(xì)胞和輔助T細(xì)胞的激活，對(duì)清除病原體、抗腫瘤免疫以及自身免疫反應(yīng)的調(diào)控具有重要作用。CD3E的功能異?？赡芘c某些免疫缺陷和自身免疫疾病相關(guān)。

熱銷(xiāo)產(chǎn)品

Recombinant Human T-cell surface glycoprotein CD3 epsilon chain (CD3E), partial (CSB-MP004931HU)

驗(yàn)證數(shù)據(jù)

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CD3E Recombinant Monoclonal Antibody (CSB-RA004931MA1HU)

驗(yàn)證數(shù)據(jù)

Overlay Peak curve showing JK cells surface stained with CSB-RA004931MA1HU (red line) at 1:100. Then 10% normal goat serum was Incubated to block non-specific protein-protein interactions followed by the antibody (1μg/1*10⁶cells) for 45 min at 4°C. The secondary antibody used was FITC-conjugated Goat Anti-Mouse IgG(H+L) at 1/200 dilution for 35 min at 4°C. Isotype control antibody (green line) was mouse IgG1 (1μg/1*10⁶cells) used under the same conditions. Acquisition of >10, 006 events was performed.