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CD40

CD40(又稱為Bp50)是一種細(xì)胞表面蛋白質(zhì),屬于腫瘤壞死因子受體超家族(TNF receptor superfamily)的成員之一,CD40是一種單鏈型跨膜蛋白,包括一個(gè)胞外區(qū)域、一個(gè)跨膜區(qū)域和一個(gè)胞漿區(qū)域。它的胞外區(qū)域可以與其配體CD40L(CD40配體)結(jié)合,觸發(fā)信號(hào)傳導(dǎo)。CD40是免疫系統(tǒng)中的關(guān)鍵調(diào)節(jié)分子,對(duì)于體液免疫應(yīng)答、免疫記憶的形成以及免疫調(diào)節(jié)都具有重要意義。它的功能擴(kuò)展到B細(xì)胞激活、抗原呈遞和炎癥調(diào)節(jié)等多個(gè)層面,因此對(duì)于理解免疫系統(tǒng)如何應(yīng)對(duì)感染、自身免疫疾病以及癌癥等疾病的研究具有重要價(jià)值。此外,CD40信號(hào)傳導(dǎo)也在免疫治療研究中被廣泛研究,以開(kāi)發(fā)新的治療方法來(lái)增強(qiáng)或抑制免疫系統(tǒng)的特定響應(yīng)。

熱銷(xiāo)產(chǎn)品

Recombinant Human Tumor necrosis factor receptor superfamily member 5(CD40),partial (Active) CSB-MP004936HU1

驗(yàn)證數(shù)據(jù)

SDS
CSB-MP004936HU1 SDS

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

ELISA
High Purity Validated of CSB-MP004936HU1

Activity: Measured by its binding ability in a functional ELISA. Immobilized CD40 at 2 μg/ml can bind CD40L (CSB-MP004937HU3), the EC50 is 3.112-3.858 ng/ml.

LSPR
High Purity Validated of CSB-MP004936HU1

Activity: Human CD40 protein hFc tag (CSB-MP004936HU1) captured on COOH chip can bind Human CD40L protein hFc and Flag tag (CSB-MP004937HU3) with an affinity constant of 2.06 nM as detected by LSPR Assay.

CD40 Antibodies

CD40 for Homo sapiens (Human)

CD40 Proteins

CD40 Proteins for Mus musculus (Mouse)

CD40 Proteins for Homo sapiens (Human)

CD40 Proteins for Bos taurus (Bovine)

CD40 Proteins for Callithrix jacchus (White-tufted-ear marmoset)

CD40 Proteins for Equus caballus (Horse)

CD40 Proteins for Canis familiaris (Dog) (Canis lupus familiaris)

CD40 Proteins for Sus scrofa (Pig)

CD40 ELISA Kit

CD40 ELISA Kit for Mus musculus (Mouse)