CDC123
CDC123,即細(xì)胞分裂周期12蛋白,別名細(xì)胞分裂周期相關(guān)蛋白。CDC123是一種高度保守的蛋白質(zhì),在多種生物體中都有發(fā)現(xiàn),包括人類、小鼠、果蠅和酵母等。它在細(xì)胞周期調(diào)控、蛋白質(zhì)折疊和應(yīng)對(duì)細(xì)胞應(yīng)激中發(fā)揮重要作用。CDC123的作用機(jī)制涉及到與多種蛋白質(zhì)的相互作用,包括與HSP90分子伴侶的結(jié)合,以及參與內(nèi)質(zhì)網(wǎng)相關(guān)降解(ERAD)過(guò)程,幫助維持蛋白質(zhì)穩(wěn)態(tài)和細(xì)胞內(nèi)環(huán)境平衡。CDC123在生物學(xué)上的意義非常廣泛,它參與了多種細(xì)胞內(nèi)信號(hào)通路,包括細(xì)胞周期進(jìn)程、蛋白質(zhì)合成、內(nèi)質(zhì)網(wǎng)應(yīng)激反應(yīng)等。CDC123的功能異常與多種疾病有關(guān),包括某些類型的癌癥、神經(jīng)退行性疾病和代謝性疾病。例如,在腫瘤細(xì)胞中,CDC123的表達(dá)水平可能與腫瘤的增殖、侵襲和轉(zhuǎn)移能力相關(guān)。此外,CDC123還可能參與調(diào)節(jié)細(xì)胞對(duì)營(yíng)養(yǎng)缺乏和氧化應(yīng)激的響應(yīng),影響細(xì)胞的生存和死亡。因此,CDC123是細(xì)胞生物學(xué)研究和相關(guān)疾病治療中的一個(gè)潛在靶點(diǎn) 。
熱銷產(chǎn)品
CDC123 Antibody (CSB-PA004984LA01HU)
驗(yàn)證數(shù)據(jù)
IHC image of CSB-PA004984LA01HU diluted at 1:500 and staining in paraffin-embedded human endometrial cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
CDC123 Antibodies
CDC123 for Homo sapiens (Human)
產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
---|---|---|---|
CSB-PA004984LA01HU | CDC123 Antibody | Human | ELISA, IHC |
CDC123 Proteins
CDC123 Proteins for Homo sapiens (Human)
產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
---|---|---|
CSB-YP004984HU CSB-EP004984HU CSB-BP004984HU CSB-MP004984HU CSB-EP004984HU-B |
Recombinant Human Cell division cycle protein 123 homolog (CDC123) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |