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CSF1R

CSF1R,即集落刺激因子1受體,別名CD115、MCSFR、Oncogen FMS、Proto-oncogene c-Fms、V-FMS McDonough feline sarcoma viral oncogen homolog、formerly。它是一種由CSF1R基因編碼的跨膜受體,屬于酪氨酸激酶受體家族成員。CSF1R在多種組織中表達(dá),尤其在單核-巨噬細(xì)胞系中表達(dá)量較高。CSF1R的作用機(jī)制主要涉及與集落刺激因子1(CSF-1)和白細(xì)胞介素34(IL-34)等配體結(jié)合,激活受體的酪氨酸激酶活性,進(jìn)而引發(fā)細(xì)胞內(nèi)信號(hào)傳導(dǎo)。配體結(jié)合導(dǎo)致受體二聚化和自磷酸化,激活下游的多個(gè)信號(hào)通路,包括PI3K/Akt、MAPK、STAT等。CSF1R參與調(diào)節(jié)單核細(xì)胞、巨噬細(xì)胞、破骨細(xì)胞的增殖、分化和存活。CSF1R信號(hào)通路的激活對于維持免疫系統(tǒng)和骨骼系統(tǒng)的正常功能至關(guān)重要。此外,CSF1R的功能異常與多種疾病有關(guān),包括某些類型的癌癥、免疫性疾病和炎癥性疾病。因此,CSF1R是藥物開發(fā)和疾病治療中的一個(gè)潛在靶點(diǎn)。

熱銷產(chǎn)品

Recombinant Human Macrophage colony-stimulating factor 1 receptor (CSF1R), partial (CSB-MP006044HUi10)

驗(yàn)證數(shù)據(jù)

CSB-MP006044HUi10

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CSF1R Antibody (CSB-PA001597)

驗(yàn)證數(shù)據(jù)

CSB-PA001597

Western Blot analysis of HT29 cells using c-Fms Polyclonal Antibody

CSB-PA001597

Western Blot analysis of HT29 cells using c-Fms Polyclonal Antibody

CSF1R Antibodies

CSF1R for Felis silvestris catus

CSF1R for Homo sapiens (Human)

CSF1R Proteins

CSF1R Proteins for Felis catus (Cat) (Felis silvestris catus)

CSF1R Proteins for Homo sapiens (Human)

CSF1R Proteins for Mus musculus (Mouse)

CSF1R Proteins for Danio rerio (Zebrafish) (Brachydanio rerio)

CSF1R ELISA Kit

CSF1R ELISA Kit for Homo sapiens (Human)

CSF1R ELISA Kit for Rattus norvegicus (Rat)