Your Good Partner in Biology Research

CTNNB1

CTNNB1,別名Armadillo、NEDSDV、MRD19、EVR7等。CTNNB1基因位于3號染色體上,編碼的蛋白質(zhì)β-連環(huán)蛋白是細(xì)胞黏附復(fù)合物的重要成分,在上皮細(xì)胞中形成粘附連接并介導(dǎo)多種組織的細(xì)胞間粘附。CTNNB1在Wnt信號通路中扮演關(guān)鍵角色,控制細(xì)胞生長和分化。在沒有Wnt信號時,β-連環(huán)蛋白被磷酸化后泛素化,并被蛋白酶體降解。Wnt信號存在時,β-連環(huán)蛋白積累并在細(xì)胞核內(nèi)與TCF/LEF家族轉(zhuǎn)錄因子結(jié)合,激活下游基因表達(dá)。CTNNB1的突變或異常激活與多種腫瘤的發(fā)生發(fā)展有關(guān),包括結(jié)直腸癌、卵巢癌、肝細(xì)胞癌等,是腫瘤治療的重要靶點。

熱銷產(chǎn)品

CTNNB1 Recombinant Monoclonal Antibody (CSB-RA155605A0HU)

驗證數(shù)據(jù)

CSB-RA155605A0HU

IHC image of CSB-RA155605A0HU diluted at 1:100 and staining in paraffin-embedded human breast cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.

CSB-RA155605A0HU

IHC image of CSB-RA155605A0HU diluted at 1:100 and staining in paraffin-embedded human liver cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.

CTNNB1 Antibodies

CTNNB1 for Homo sapiens (Human)

CTNNB1 for H, M, R

CTNNB1 for Human, Mouse, Rat

CTNNB1 Proteins

CTNNB1 Proteins for Homo sapiens (Human)

CTNNB1 Proteins for Xenopus laevis (African clawed frog)

CTNNB1 Proteins for Bos taurus (Bovine)

CTNNB1 Proteins for Rattus norvegicus (Rat)

CTNNB1 ELISA Kit

CTNNB1 ELISA Kit for Homo sapiens (Human)

CTNNB1 ELISA Kit for Mus musculus (Mouse)