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CTSK

CTSK,即組織蛋白酶K。別名Cathepsin K,它是一種由破骨細(xì)胞分泌的半胱氨酸蛋白酶,對(duì)骨吸收過(guò)程中的基質(zhì)膠原的降解至關(guān)重要。CTSK主要在破骨細(xì)胞中表達(dá),但在其他類型的細(xì)胞中也有發(fā)現(xiàn),如軟骨細(xì)胞和某些腫瘤細(xì)胞。CTSK在降解骨基質(zhì)中起關(guān)鍵作用,其活性受多種因素調(diào)節(jié),包括pH值和特異性抑制劑。CTSK的作用機(jī)制涉及其對(duì)骨基質(zhì)中膠原蛋白的降解,這一過(guò)程對(duì)骨重塑和礦化至關(guān)重要。CTSK的異常表達(dá)或活性與多種疾病相關(guān),包括但不限于骨疾病和腫瘤。在癌癥中,CTSK可能參與腫瘤的生長(zhǎng)和轉(zhuǎn)移,其表達(dá)水平的變化與腫瘤的侵襲性和預(yù)后相關(guān)。CTSK被認(rèn)為是治療骨質(zhì)疏松癥和某些癌癥的潛在靶點(diǎn)。

熱銷產(chǎn)品

Recombinant Human Cathepsin K (CTSK) (CSB-EP006192HU)

驗(yàn)證數(shù)據(jù)

CSB-EP006192HU

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CTSK Antibody (CSB-PA006192ESR1HU)

驗(yàn)證數(shù)據(jù)

CSB-PA006192ESR1HU

Western blot
All lanes: CTSK antibody at 8μg/ml
Lane 1: MCF-7 whole cell lysate
Lane 2: Rat brain tissue
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 37 kDa
Observed band size: 37 kDa

CSB-PA006192ESR1HU

Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA006192ESR1HU at dilution of 1:100

CSB-PA006192ESR1HU

Immunohistochemistry of paraffin-embedded human placenta tissue using CSB-PA006192ESR1HU at dilution of 1:100

Human Cathepsin K,cath-K ELISA Kit (CSB-E09438h)

驗(yàn)證數(shù)據(jù)

CSB-E09438h 標(biāo)準(zhǔn)曲線

貨號(hào):CSB-E09438h

規(guī)格:96T/48T

靈敏度:1.95 pg/mL

檢測(cè)范圍:7.8 pg/mL-500 pg/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

CTSK Antibodies

CTSK for Rattus norvegicus (Rat)

CTSK for Homo sapiens (Human)

CTSK Proteins

CTSK Proteins for Homo sapiens (Human)

CTSK Proteins for Oryctolagus cuniculus (Rabbit)

CTSK Proteins for Mus musculus (Mouse)

CTSK Proteins for Macaca mulatta (Rhesus macaque)

CTSK Proteins for Rattus norvegicus (Rat)

CTSK Proteins for Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)

CTSK Proteins for Gallus gallus (Chicken)

CTSK Proteins for Sus scrofa (Pig)

CTSK Proteins for Canis familiaris (Dog) (Canis lupus familiaris)

CTSK Proteins for Bos taurus (Bovine)

CTSK Proteins for Canis lupus familiaris (Dog) (Canis familiaris)

CTSK ELISA Kit

CTSK ELISA Kit for Homo sapiens (Human)

CTSK ELISA Kit for Mus musculus (Mouse)

CTSK ELISA Kit for Rattus norvegicus (Rat)