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DPP4

DPP4,即二肽基肽酶4,別名DPP-4抑制劑。它是一種細胞表面的絲氨酸蛋白酶,主要在腸道中表達,也在肝臟、胰腺、胎盤、胸腺等部位表達。DPP4的作用機制主要是滅活多種生物活性肽,包括胰高血糖素樣肽-1(GLP-1)和葡萄糖依賴性促胰島素分泌多肽(GIP),這兩種激素都是DPP-4的靶蛋白,可被DPP-4迅速降解和失活 。DPP4在生物學上的意義主要體現(xiàn)在其參與調(diào)節(jié)血糖水平的過程中。DPP-4抑制劑通過抑制DPP-4的活性,減少GLP-1及GIP的降解,從而增強胰島素的分泌并降低血糖。DPP-4抑制劑具有葡萄糖依賴性的降糖作用,低血糖風險低,并且具有減輕體重、改善胰島β細胞功能等額外益處 。此外,DPP-4還可能在肥胖誘導的炎癥和胰島素抵抗中起關鍵作用,DPP-4抑制劑的使用可以減輕肥胖引起的炎癥反應和胰島素抵抗 。

熱銷產(chǎn)品

Recombinant Human Dipeptidyl peptidase 4 (DPP4), partial (CSB-MP007139HU1)

驗證數(shù)據(jù)

CSB-MP007139HU1

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

DPP4 Recombinant Monoclonal Antibody (CSB-RA927191A0HU)

驗證數(shù)據(jù)

CSB-RA927191A0HU

IHC image of CSB-RA927191A0HU diluted at 1:100 and staining in paraffin-embedded human prostate cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.

DPP4 Antibodies

DPP4 for Homo sapiens (Human)

DPP4 Proteins

DPP4 Proteins for Bos taurus (Bovine)

DPP4 Proteins for Rattus norvegicus (Rat)

DPP4 Proteins for Sus scrofa (Pig)

DPP4 Proteins for Homo sapiens (Human)

DPP4 Proteins for Mus musculus (Mouse)

DPP4 Proteins for Trichophyton equinum (Horse ringworm fungus)

DPP4 Proteins for Trichophyton tonsurans (Scalp ringworm fungus)

DPP4 Proteins for Arthroderma otae (strain ATCC MYA-4605 / CBS 113480) (Microsporum canis)

DPP4 Proteins for Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)

DPP4 Proteins for Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181) (Aspergillus fischerianus)

DPP4 Proteins for Aspergillus flavus (strain ATCC 200026 / FGSC A1120 / NRRL 3357 / JCM 12722 / SRRC 167)

DPP4 Proteins for Arthroderma benhamiae (strain ATCC MYA-4681 / CBS 112371) (Trichophyton mentagrophytes)

DPP4 Proteins for Trichophyton verrucosum (strain HKI 0517)

DPP4 Proteins for Neosartorya fumigata (strain CEA10 / CBS 144.89 / FGSC A1163) (Aspergillus fumigatus)

DPP4 Proteins for Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold)

DPP4 Proteins for Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)

DPP4 Proteins for Trichophyton rubrum (Athlete's foot fungus) (Epidermophyton rubrum)

DPP4 Proteins for Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)

DPP4 Proteins for Felis catus (Cat) (Felis silvestris catus)

DPP4 ELISA Kit

DPP4 ELISA Kit for Homo sapiens (Human)

DPP4 ELISA Kit for Mus musculus (Mouse)

DPP4 ELISA Kit for Rattus norvegicus (Rat)