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ERBB3

ERBB3(又稱HER3,人表皮生長因子受體3)屬于表皮生長因子受體家族(EGFR)。ERBB3在正常成人的胃腸道、生殖系統(tǒng)、皮膚、神經(jīng)系統(tǒng)、泌尿道和內(nèi)分泌系統(tǒng)中均有表達(dá)。事實(shí)上,ERBB3本身受到不同程度的調(diào)控,由2個泛素連接酶NEDD4和NRDP1調(diào)控其泛素化和蛋白體降解。ERBB3胞內(nèi)區(qū)無內(nèi)在的酪氨酸激酶活性不能自身磷酸化,但ERBB3能夠與表皮生長因子受體家族其它成員,ERBB1(又稱EGFR,HER1)、ERBB2/HER2和ERBB4/HER4形成異源性二聚體,激活下游通路,影響細(xì)胞的增殖分化。其中ERBB3/ERBB2復(fù)合物能夠激活MAPK/ERK和PI3K/AKT在內(nèi)的多種通路。大量研究表明, ERBB3過表達(dá)可見于乳腺癌、肺癌、結(jié)直腸癌、胃癌、頭頸鱗癌、卵巢癌、黑色素瘤、前列腺癌和膀胱癌等。因此,通過靶向ERBB3,阻斷ERBB3/ERBB2通路,正在為癌癥治療提供新途徑。

Recombinant Human ERBB3 活性蛋白實(shí)驗(yàn)驗(yàn)證數(shù)據(jù)

High Purity Validated by SDS-PAGE

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Excellent Bioactivity Validated by Functional ELISA

Measured by its binding ability in a functional ELISA. Immobilized NRG1(CSB-MP016077HU1(F6)) at 2 μg/ml can bind human ERBB3, the EC50 is 12.32-15.74 ng/ml.


ERBB3 Antibodies

ERBB3 for Homo sapiens (Human)

ERBB3 Proteins

ERBB3 Proteins for Homo sapiens (Human)

ERBB3 Proteins for Rattus norvegicus (Rat)

ERBB3 Proteins for Pongo abelii (Sumatran orangutan)

ERBB3 Proteins for Mus musculus (Mouse)

ERBB3 ELISA Kit

ERBB3 ELISA Kit for Homo sapiens (Human)