FAP
FAP，即成纖維細(xì)胞激活蛋白，別名Fibroblast Activation Protein-α、FAP-α。它是一種II型跨膜絲氨酸蛋白酶，通常在正常組織中表達(dá)量很低，但在纖維化、關(guān)節(jié)炎和癌癥等病理性疾病中表達(dá)顯著升高。FAP的作用機(jī)制包括促進(jìn)腫瘤細(xì)胞的增殖、侵襲、血管生成、上皮向間質(zhì)轉(zhuǎn)化、干細(xì)胞促進(jìn)、免疫抑制和耐藥，其活性與腫瘤生長(zhǎng)和轉(zhuǎn)移密切相關(guān)。FAP通過(guò)與β-整合素結(jié)合，協(xié)同促進(jìn)腫瘤細(xì)胞的增殖、遷移和侵襲，其促血管生成特性歸因于它的二肽基肽酶活性，其作用底物神經(jīng)肽Y在裂解后能促血管生成和促進(jìn)內(nèi)皮細(xì)胞遷移。FAP的下游信號(hào)通路主要包括PI3K/AKT、RAS/ERK、SHH/GLI、FAK等 。
熱銷(xiāo)產(chǎn)品
Recombinant Human Prolyl endopeptidase FAP (FAP), partial (CSB-EP008424HUa0)
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
FAP Antibody (CSB-PA614259ESR2HU)
驗(yàn)證數(shù)據(jù)
Immunohistochemistry of paraffin-embedded human small intestine tissue using CSB-PA614259ESR2HU at dilution of 1:100
Immunohistochemistry of paraffin-embedded human skin tissue using CSB-PA614259ESR2HU at dilution of 1:100
FAP Antibodies
FAP for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 種屬反應(yīng)性 | 應(yīng)用類(lèi)型 |
|---|---|---|---|
| CSB-PA614259ESR2HU | FAP Antibody | Human | ELISA, IHC |
| CSB-PA101830 | FAP Antibody | Human,Mouse | ELISA,WB,IHC |
| CSB-PA008191 | FAP Antibody | Human,Mouse,Rat | WB, ELISA |
| CSB-PA949422 | FAP Antibody | Human,Mouse | ELISA,IHC |
| CSB-PA699536 | FAP Antibody | Human,Mouse | ELISA,IHC |
FAP Proteins
FAP Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP008424HU CSB-BP008424HU CSB-MP008424HU CSB-EP008424HU-B |
Recombinant Human Prolyl endopeptidase FAP (FAP), partial | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP008424HU | Recombinant Human Prolyl endopeptidase FAP (FAP), partial | E.coli |
| CSB-EP008424HUa0 | Recombinant Human Prolyl endopeptidase FAP (FAP), partial | E.coli |
FAP ELISA Kit
FAP ELISA Kit for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 樣本類(lèi)型 | 靈敏度 |
|---|---|---|---|
| CSB-EL008424HU | Human Seprase(FAP) ELISA kit | serum, plasma,tissue homogenates | 0.078 ng/mL |
