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FOXO1

FOXO1,即叉頭框蛋白O1,它是一種在多種細胞類型中表達的轉錄因子。FOXO1主要通過響應細胞內外的信號,如PI3K/AKT信號通路的激活,來調節(jié)細胞的增殖、凋亡、代謝和應激反應等生命活動。其作用機制涉及到FOXO1蛋白的磷酸化、乙?;确g后修飾,這些修飾影響其在細胞核與細胞質間的穿梭,進而調控其靶基因的表達。FOXO1參與的主要信號通路包括PI3K/AKT、Wnt/β-catenin、JAK/STAT等,這些通路在細胞生理過程中發(fā)揮著關鍵作用。在生物學意義上,F(xiàn)OXO1對維持細胞穩(wěn)態(tài)、調節(jié)免疫反應、影響腫瘤發(fā)生發(fā)展等具有重要作用,其活性的異常可能導致多種疾病的發(fā)生,包括糖尿病、心血管疾病和腫瘤等。

熱銷產品

FOXO1 Antibody (CSB-PA16019A0Rb)

驗證數(shù)據

CSB-PA16019A0Rb

Western Blot
Positive WB detected in: Mouse brain tissue, Mouse lung tissue
All lanes: FOXO1 antibody at 2.5μg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 70 kDa
Observed band size: 70 kDa

CSB-PA16019A0Rb

Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA16019A0Rb at dilution of 1:100

CSB-PA16019A0Rb

Immunofluorescent analysis of Hela cells using CSB-PA16019A0Rb at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

FOXO1 Antibodies

FOXO1 for Homo sapiens (Human)

FOXO1 Proteins

FOXO1 Proteins for Homo sapiens (Human)

FOXO1 Proteins for Xenopus laevis (African clawed frog)

FOXO1 Proteins for Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)

FOXO1 Proteins for Spermophilus tridecemlineatus (Thirteen-lined ground squirrel) (Ictidomys tridecemlineatus)

FOXO1 Proteins for Mus musculus (Mouse)