GABRA1
GABRA1，即γ-氨基丁酸A型受體亞單位α1，別名EJM、ECA4、EJM5、DEE19、EIEE19等。GABRA1基因位于人類第5號染色體上，編碼的蛋白質(zhì)是GABAA受體α1亞單位，這是一種配體門控的氯離子通道，主要在中樞神經(jīng)系統(tǒng)中起作用。GABRA1的作用機制是通過與GABA結(jié)合，調(diào)節(jié)氯離子通道的開啟，導(dǎo)致神經(jīng)元細胞膜的超極化，從而降低神經(jīng)元的興奮性，產(chǎn)生抑制性突觸后電位。GABRA1在生物學(xué)意義上非常重要，它參與調(diào)節(jié)神經(jīng)系統(tǒng)的興奮性，對于維持神經(jīng)系統(tǒng)的正常功能至關(guān)重要。GABRA1基因的突變與某些類型的癲癇如青少年肌陣攣性癲癇和兒童失神性癲癇有關(guān)，是研究癲癇等疾病的重要靶點。
熱銷產(chǎn)品
驗證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
GABRA1 Antibody (CSB-PA100614)
驗證數(shù)據(jù)
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA100614(GABRA1 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: ×200)
The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using CSB-PA100614(GABRA1 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: ×200)
Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Human stomach cancer tissue, LoVo cells, Primary antibody: CSB-PA100614(GABRA1 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 minutes
GABRA1 Antibodies
GABRA1 for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA009140GA01HU | GABRA1 Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA006146 | GABRA1 Antibody | Human,Mouse,Rat | WB, ELISA |
| CSB-PA008555 | GABRA1 Antibody | Human,Mouse,Rat | IHC, ELISA |
| CSB-PA100614 | GABRA1 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA522630 | GABRA1 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
GABRA1 Proteins
GABRA1 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP009140HU CSB-BP009140HU CSB-MP009140HU CSB-EP009140HU-B |
Recombinant Human Gamma-aminobutyric acid receptor subunit alpha-1 (GABRA1), partial | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP009140HU | Recombinant Human Gamma-aminobutyric acid receptor subunit alpha-1 (GABRA1), partial | E.coli |
