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GPC3

GPC3是一種糖蛋白,具有特定的蛋白質(zhì)結(jié)構(gòu),其中包括一個胞外糖基化的部分和一個胞漿部分??梢耘c多種生長因子、信號分子和受體相互作用,從而影響細胞信號傳導(dǎo)通路。它可以促進或抑制特定信號通路的激活,因此對于細胞生長、增殖和分化等過程具有調(diào)節(jié)作用。在胚胎發(fā)育中,GPC3對于正常器官和組織的形成至關(guān)重要。它在特定發(fā)育階段參與胚胎體軸的建立、四肢發(fā)育和器官的分化。 GPC3異常表達會影響疾病的發(fā)生發(fā)展,研究GCP3的功能和調(diào)節(jié)機制對于理解疾病的發(fā)病機制和開發(fā)相關(guān)治療方法具有重要意義。

更多相關(guān)閱讀:靶向GPC3在肝癌中初顯成效,未來聯(lián)合治療潛力更大

熱銷產(chǎn)品

Recombinant Human Glypican-3(GPC3)(G537R),partial (Active) CSB-MP009705HU(M)

驗證數(shù)據(jù)

SDS
CSB-MP009705HU(M) SDS

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

ELISA
High Purity Validated of CSB-MP009705HU(M)

Activity: Measured by its binding ability in a functional ELISA. Immobilized human GPC3 (G537R) at 5 μg/ml can bind Anti-GPC3 recombinant antibody, the EC50 is 4.739-7.092 ng/ml.

GPC3 Recombinant Monoclonal Antibody CSB-RA009705A0HU

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WB
CSB-RA009705A0HU WB

Western Blot
Positive WB detected in: 293 whole cell lysate, K562 whole cell lysate All lanes: GPC3 antibody at 0.9μg/ml. Secondary, Goat polyclonal to rabbit IgG at 1/50000 dilution Predicted band size: 66, 60, 69 KDa Observed band size: 66 KDa

IF
CSB-RA009705A0HU IF

Immunofluorescence staining of HepG2 cells with CSB-RA009705A0HU at 1:30, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG (H+L).

CT26/Human GPC3 Stable Cell Line CSB-SC009705HU2

驗證數(shù)據(jù)

ELISA
CSB-SC009705HU2-FACS

Untransfected CT26 cells (green line) and transfected Human GPC3 CT26 Stable cells (red line) were stained with anti-GPC3 antibody(CSB-RA009705A1HU) (2µg/1*106cells), washed and then followed by APC-conjugated anti-Human IgG Fc antibody and analyzed with flow cytometry.

GPC3 Antibodies

GPC3 for Homo sapiens (Human)

GPC3 Proteins

GPC3 Proteins for Rattus norvegicus (Rat)

GPC3 Proteins for Homo sapiens (Human)

GPC3 Proteins for Pan troglodytes (Chimpanzee)

GPC3 Proteins for Mus musculus (Mouse)

GPC3 ELISA Kit

GPC3 ELISA Kit for Homo sapiens (Human)

GPC3 ELISA Kit for Mus musculus (Mouse)

GPC3 ELISA Kit for Rattus norvegicus (Rat)