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GSDME

GSDME,別名DFNA5、ICERE-1。它來源于人體細(xì)胞,是一種具有膜穿孔活性的蛋白質(zhì)。GSDME在細(xì)胞中的作用機(jī)制主要是通過被Caspase 3切割激活,誘導(dǎo)細(xì)胞從凋亡向細(xì)胞焦亡轉(zhuǎn)換。在生物學(xué)上,GSDME具有多重意義,包括參與神經(jīng)退行性疾病的發(fā)生、調(diào)節(jié)炎癥反應(yīng),以及作為癌癥免疫療法的潛在靶點(diǎn)。它的發(fā)現(xiàn)和研究為理解細(xì)胞死亡機(jī)制、治療神經(jīng)退行性疾病和癌癥提供了新的視角和策略。

熱銷產(chǎn)品

Recombinant Human Gasdermin-E (GSDME) (CSB-EP006766HU)

驗(yàn)證數(shù)據(jù)

CSB-EP006766HU

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

GSDME Antibody (CSB-PA006766LA01HU)

驗(yàn)證數(shù)據(jù)

CSB-PA006766LA01HU

Immunohistochemistry of paraffin-embedded human thyroid tissue using CSB-PA006766LA01HU at dilution of 1:100

CSB-PA006766LA01HU

Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA006766LA01HU at dilution of 1:100

CSB-PA006766LA01HU

Immunofluorescent analysis of Hela cells using CSB-PA006766LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

GSDME Antibodies

GSDME for Homo sapiens (Human)

GSDME Proteins

GSDME Proteins for Homo sapiens (Human)