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GUCY2C

鳥苷酸環(huán)化酶C (guanylyl cyclase C,GUCY2C/GCC)屬于受體鳥苷酸環(huán)化酶家族中的一員。該酶是細(xì)菌熱穩(wěn)定腸毒素的腸道受體,所以GUCY2C又稱為熱穩(wěn)定腸毒素受體,主要參與調(diào)節(jié)腸道內(nèi)水和電解質(zhì)的平衡。在正常人機(jī)體組織中,GUCY2C主要表達(dá)于腸上皮細(xì)胞,在腸外組織和腫瘤中不表達(dá)。鳥苷素(guanylin,Gn)、尿鳥苷素(uroguanylin,Ugn)以及熱穩(wěn)定性腸毒素(heat-stable enterotoxin,STa)是GUCY2C的配體。當(dāng)這些配體(Gn/Ugn/STa)與GUCY2C結(jié)合后,能激活GUCY2C,發(fā)揮生物學(xué)效應(yīng)。GUCY2C主要與腸道疾病相關(guān),以及較少報(bào)道的神經(jīng)疾病。其中,腸道類相關(guān)的疾病主要包括功能性胃腸病(例如過敏性腸綜合癥,便秘,或酸度過量等)、炎癥性腸?。ɡ缈肆_恩病和潰瘍性結(jié)腸炎等)、癌癥(例如胃腸道癌癥)。針對(duì)GUCY2C這個(gè)靶點(diǎn)的腫瘤藥物開發(fā),已有國內(nèi)上海斯丹賽生物技術(shù)有限公司的GUCY2C CAR-T 細(xì)胞療法,以及輝瑞公司的GUCY2C-CD3雙特異性抗體PF-0706119等等。

Recombinant Human GUCY2C 活性蛋白實(shí)驗(yàn)驗(yàn)證數(shù)據(jù)

High Purity Validated by SDS-PAGE

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Excellent Bioactivity Validated by Functional ELISA

Measured by its binding ability in a functional ELISA. Immobilized human GUCY2C at 5 μg/ml can bind Anti-GUCY2C recombinant antibody (CSB-RA010053A2HU), the EC50 is 3.049-4.660 ng/mL.


GUCY2C Antibodies

GUCY2C for Homo sapiens (Human)

GUCY2C Proteins

GUCY2C Proteins for Cavia porcellus (Guinea pig)

GUCY2C Proteins for Rattus norvegicus (Rat)

GUCY2C Proteins for Sus scrofa (Pig)

GUCY2C Proteins for Homo sapiens (Human)

GUCY2C Proteins for Mus musculus (Mouse)