Your Good Partner in Biology Research

IL17RB

IL17RB,即白介素17受體B”,別名IL-17RB。它是一種I型跨膜蛋白,屬于IL-17受體家族成員之一,由人體細(xì)胞自身的基因編碼。IL17RB的作用機(jī)制涉及到與特定的配體如IL-25(也稱為IL-17E)結(jié)合,這一結(jié)合激活了下游的信號傳導(dǎo)途徑。IL17RB與IL-17RA一起參與形成功能性的受體復(fù)合物,這種復(fù)合物對于IL-25的信號傳導(dǎo)至關(guān)重要。IL17RB通過其細(xì)胞外的纖連蛋白III型結(jié)構(gòu)域與配體結(jié)合,并通過其細(xì)胞質(zhì)內(nèi)的SEFIR結(jié)構(gòu)域傳遞信號,激活細(xì)胞內(nèi)的信號通路。IL17RB在生物學(xué)上的意義主要體現(xiàn)在其參與調(diào)節(jié)免疫反應(yīng)和炎癥過程。作為IL-25的受體之一,IL17RB在Th2型免疫應(yīng)答中發(fā)揮重要作用,影響過敏性疾病如哮喘和過敏性皮炎的病理過程。此外,IL17RB還與腫瘤發(fā)展相關(guān),例如在乳腺癌中,IL17RB信號通路的激活可能促進(jìn)腫瘤細(xì)胞的增殖和存活,因此靶向IL17RB信號通路可能成為抑制該疾病的一種潛在治療策略。IL17RB的活性還與多種細(xì)胞因子和趨化因子的產(chǎn)生相關(guān),通過激活MAPK、NF-κB和C/EBPs等信號途徑,進(jìn)而影響宿主的免疫反應(yīng)。

熱銷產(chǎn)品

IL17RB Antibody (CSB-PA882088ESR1HU)

驗(yàn)證數(shù)據(jù)

CSB-PA882088ESR1HU

Western blot
All lanes: IL17RB antibody at 2.16µg/ml
Lane 1: 293T whole cell lysate
Lane 2: Hela whole cell lysate
Lane 3: HepG2 whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 56, 32 kDa
Observed band size: 56, 32 kDa

CSB-PA882088ESR1HU

Immunohistochemistry of paraffin-embedded human liver tissue using CSB-PA882088ESR1HU at dilution of 1:100

CSB-PA882088ESR1HU

Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA882088ESR1HU at dilution of 1:100

IL17RB Antibodies

IL17RB for Homo sapiens (Human)

IL17RB Proteins

IL17RB Proteins for Mus musculus (Mouse)

IL17RB Proteins for Homo sapiens (Human)

IL17RB ELISA Kit

IL17RB ELISA Kit for Homo sapiens (Human)